晚期子宫内膜癌预后及其影响因素的分析  

Analysis of survival and prognostic factors for patients with advanced stage endometrial carcinoma

作　　者：李淑敏[1] 章文华[1] 白萍[1] 李洪君[1] 于靖蓉[1] 李斌[1] 吴令英[1] 张蓉[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院妇瘤科,北京100021

出　　处：《中华肿瘤防治杂志》2008年第20期1587-1589,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨晚期子宫内膜癌的预后及其影响因素,为确定预测晚期子宫内膜癌预后的指标提供一定的依据。方法:回顾性分析手术初治的81例晚期子宫内膜癌患者的病例资料,用Ka-plan-Meier法和Log-rank检验分析患者总的5年生存及年龄、肿瘤分期、肿瘤细胞分级、肌层浸润深度、腹腔冲洗液或腹水细胞学、治疗前血清CA125水平、术后残存肿瘤大小及术后辅助治疗方法与生存的关系,Cox比例风险模型进行多因素分析。结果:总的5年生存率为54.3%。单因素分析显示,肿瘤分期(χ2=37.419,P=0.000)、肿瘤细胞分级(χ2=13.536,P=0.001)、肌层浸润深度(χ2=11.641,P=0.009)和术后辅助治疗方法(χ2=19.102,P=0.000)与晚期子宫内膜癌的生存显著相关;而多因素分析仅显示肿瘤分期(χ2=9.32,P=0.002)是晚期子宫内膜癌的重要预后影响因素。结论:晚期子宫内膜癌的预后差,肿瘤分期是影响其生存的重要因素,是独立预后指标。OBJECTIVE： To explore the survival and prognostic factors for patients with advanced stage endometrial carcinoma, and identify the prognostic markers of advanced stage endometrial carcinoma. METHODS： Eighty-one patients with advanced stage endometrial carcinoma who were primarily operated in our hospital were analyzed retrospectively, and the correlation of the five-year survival rate was evaluated with the age, FIGO stage, tumor grade, the depth of myometrial invasion, peritoneal washing or ascites cytology, serum CA125 of pretreatment, the diameter of postoperative residual tumor and postoperative adjuvant therapy by the Kaplan Meier method and Log-rank test, and the multivariahles was analyzed by Cox proportional hazard models. RESULTS： The overall 5-year survival rate was 54.3% for 81 patients with advanced stage endometrial carcinoma. FIGO stage （χ^2= 37. 419, P=0. 000）, the tumor grade（χ^2 =13.536, P=0.001）, the depth of myometrial invasion（χ^2 = 11. 641, P= 0. 009） and the postoperative adjuvant therapy（χ^2 = 19. 102, P = 0. 000） were significantly correlated with the 5-year survival of advanced stage endometrial carcinoma by univariate analysis. However, the multivariate analysis revealed only FIGO stage was significantly associated with the prognosis of advanced stage endometrial carcinoma, χ^2= 9.32, P = 0. 002. CONCLUSION： The prognosis is poor for advanced stage endometrial carcinoma, and FIGO stage is a significant prognostic factor and independently affects on the survival of advanced stage endometrial carcinoma.

关 键 词：子宫内膜肿瘤 预后 肿瘤分期 回顾性研究 

分 类 号：R737.33[医药卫生—肿瘤]