DIAPH2和FMNL1在大肠癌组织中的表达及其临床意义  

Expressions of DIAPH2 and FMNL1 in colorectal carcinoma and its clinical implication

作　　者：李余发[1] 朱曦龄[1] 肖法嫚[1] 梁莉[1] 丁彦青[1] 

机构地区：[1]南方医科大学,广州市510515

出　　处：《实用医学杂志》2009年第1期47-49,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:30400206)

摘　　要：目的:研究成蛋白(formin)家族中DIAPH2(diaphanous homolog2)和FMNL1(formin-like1)在大肠癌及癌旁正常组织中的表达及其与肿瘤细胞分化、浸润、转移等生物学行为的关系。方法:用免疫组织化学SP法检测70例大肠癌及50例癌旁正常组织中DIAPH2和FMNL1蛋白的表达水平。结果:大肠癌组织中DIAPH2和FMNL1的表达均明显高于癌旁正常组织(P<0.05);低分化癌组织中DIAPH2表达高于中、高分化癌组织(P<0.05),而FMNL1在低分化和中、高分化癌组织中没有明显差异(P>0.05);DIAPH2和FMNL1与大肠癌的浸润深度无关(P>0.05);DIAPH2和FMNL1表达与淋巴结转移有关(P<0.05)。结论:Formin家族蛋白DIAPH2和FMNL1的表达与大肠癌的转移相关,有可能作为一种新的转移指标用于临床。Objective To research the expressions of diaphanous homolog 2 （DIAPH2） and formin-like 1 （FMNL1）, members of formin protein family in colorectal earcinoma（CRC） and adjacent normal tissue and study their relations with clinic opathological behaviors such as tumor cell differentiation, invasion and metastasis. Methods An immunohistochemical technique was used to detect the expression levels of DIAPH2 and FMNL1 protein in 70 cases of CRC tissues and 50 cases of adjacent normal tissues. Results The expressions of DIAPH2 and FMNL1 in CRC tissues were significantly higher than those in the adjacent tissues （P 〈 0.05）. Expressions of DIAPH2 in poorly differentiated CRC tissues were higher than those in well-differentiated carcinoma （P 〈 0.05）, while there were no differences between the expressions of FMNL1 in different types of carcinoma. The DIAPH2 and FMNLI expressions were correlated with the metastasis （P 〈 0.05） but not with infiltration depth （P 〉 0.05） of CRC. Conclusion The two formin family proteins, DIAPH2 and FMNL1, expressions were correlated with CRC and might be used as new valuable markers for the progression of CRC.

关 键 词：结直肠肿瘤 免疫组织化学 DIAPH2 FMNL1 成蛋白家族 

分 类 号：R735.34[医药卫生—肿瘤] R737.31[医药卫生—临床医学]