肉桂挥发油对阿魏酸透皮吸收影响的研究  

Promoting Effect of Cinnamon Oil on Percutaneous Sbsorption of Ferulic Acid

作　　者：高春华[1] 张亚秋[1] 王亚娟[1] 于玲[1] 

机构地区：[1]辽宁医学院药学院,辽宁锦州121001

出　　处：《辽宁中医杂志》2009年第1期100-101,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:研究肉桂挥发油对阿魏酸透皮吸收的影响。方法:采用离体昆明种小白鼠皮肤为渗透屏障,以阿魏酸为指标成分,应用Tp-6型透皮吸收扩散仪和HPLC检测方法,考察肉桂挥发油对阿魏酸透皮吸收的影响。结果:肉桂挥发油对阿魏酸的透皮吸收有一定的促进作用,并强于氮酮,其中1%肉桂挥发油对阿魏酸的促进作用优于2%肉桂挥发油。结论:肉桂挥发油能促进阿魏酸的透皮吸收。Objective ： To study the accelerative effect of Cinnamon oil on pereutaneous absorption of ferulic Acid. Methods ： The penetration experiment was performed on the Tp- 6 diffusion cell device,with isolated mouse skin, Ferulic acid as an index and HPLC method. Results：1% ,2% Cinnamon oil possessed the promoting effect and were stronger than Azone on percutaneous absorption of ferulic Acid,and 1% Cinnamon oil was stronger than 2% Cinnamon oil in promoting effect. Cinnamon oil in combination with 10% ethanol on enhancing the pereutaneous absorption of ferulic Acid did not reveal any cooperative effect. Conclusion： Cinnamon oil can be used to enhance the percutaneous absorption of femlie Acid.

关 键 词：肉桂挥发油 阿魏酸 促渗剂 

分 类 号：R285.5[医药卫生—中药学]