坛紫菜多糖及其降解产品对免疫细胞增殖的影响  

Effects of Degraded and Natural Polysaccharides from Porphyra Haitanensis on Proliferation of Lymphocytes

作　　者：赵婷婷[1] 张全斌[2] 李智恩[2] 徐祖洪[2] 

机构地区：[1]中日友好医院临床研究所药理室,北京100029 [2]中科院海洋所海洋化学室,山东青岛266071

出　　处：《中药新药与临床药理》2009年第1期30-32,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：山东省优秀中青年科学家奖励基金(2007BS07004)。

摘　　要：目的分析坛紫菜多糖及其降解产品的性质,测定其对免疫细胞增殖的影响。方法用红外光谱鉴定坛紫菜多糖P及其降解产品P3。采用体外培养方法测定不同浓度的P和P3对T、B淋巴细胞增殖的影响。结果坛紫菜多糖及其降解产品对淋巴细胞增殖有显著影响,呈剂量依赖性,两者能显著促进T细胞增殖、抑制B细胞增殖,且分子量较小的降解产品效果更明显。结论坛紫菜多糖及其降解产品对淋巴细胞增殖具有调节作用,该作用可能与分子量有关。Objective To analyze the property of natural polysaccharides （P） from Porphyra haitanensis T. J. Chang et B. F. Zheng and its degraded polysaccharides （P3）, and to investigate their effects on proliferation of lymphoeytes. Methods P3 and P were identified by IR spectra. Their effects on immunological function were studied by cell culture technique. Results P3 and P displayed significant effects on promoting the proliferation of T - lymphocytes, and had inhibitory effects on the proliferation of B - lymphocytes in a dose - dependent manner. The effects of P3 were more powerful than P. Conclusion The degraded and natural polysaccharides from Porphyra haitanensis （P3 and P） can regulate the proliferation of lymphocytes, which may be related to their molecular weights.

关 键 词：坛紫菜 多糖 T细胞 B细胞 

分 类 号：R285.5[医药卫生—中药学]