基质细胞衍生因子-1及其受体CXCR4在白血病中表达的临床意义  

Expression and clinical significance of stromal cell-derived factor-1 and its receptor CXCR4 in leukemia

作　　者：陈晨(综述)[1] 时昊(审校)[1] 

机构地区：[1]泰山医学院附属医院血液内科,271000

出　　处：《白血病．淋巴瘤》2009年第1期57-59,共3页Journal of Leukemia & Lymphoma

摘　　要：基质细胞衍生因子-1（SDF-1）是早期细胞生长因子，属趋化因子亚家族成员之一。其受体是CXCR4、SDF-1、CXCR4配体受体系统在血细胞的生成、干细胞归巢、血管新生以及白血病细胞的浸润等生理和病理过程中发挥重要作用。研究CXCR4在白血病中的表达及其与白血病浸润的关系，对丰富白血病形态学、免疫学、细胞遗传学（MIC）诊断分型的免疫学指标，为防治白血病浸润、复发而采取相关分子靶向治疗都具有重要意义。Stromal cell-derived factor-1 （SDF-1） is an early cell growth factor which belongs to a subfamily of chemokines. The CXCR4 is SDF-1 receptor. The SDF-1 interacting with CXCR4 plays important roles in physiological and pathological processes such as hematopiesis, stem cell homing, angiogenesis and leukemic cells infiltrating. To study the expression of CXCR4 in leukemia and the relationship between CXCR4 and leukemic ceils infiltration can add indicators for leukemic MIC diagnosis of immunology indexes and have great significance to take molecule targeted therapy for preventing leukemia from infiltration or relapse as well.

关 键 词：白血病 趋化因子类 基质细胞衍生因子-1 受体 G-蛋白耦联 

分 类 号：R363.2[医药卫生—病理学] R737.9[医药卫生—基础医学]