血管内皮生长因子及微血管密度在卵巢浆液性肿瘤中的表达  

Angiogenesis in serous ovarian neoplasms

作　　者：李明娥 马利国 彭芝兰[2] 王和[2] 姚先莹[2] 

机构地区：[1]暨南大学第二临床医学院深圳市人民医院妇科,深圳518020 [2]四川大学华西第二医院妇科

出　　处：《肿瘤研究与临床》2009年第1期29-31,共3页Cancer Research and Clinic

摘　　要：目的探讨卵巢浆液眭肿瘤组织中的血管生成状况。方法采用免疫组织化学方法检测76例卵巢浆液性肿瘤中微血管密度（MVD）及血管内皮生长因子（VEGF）表达状况并分析二者间相关关系。结果良性、交界性及恶性浆液性卵巢肿瘤组织中MVD值及VEGF表达呈逐渐增高趋势，MVD值分别为7．8±2．4、17．5±3．3及27．6±7．5，VEGF的表达分别为（16．1±3．9）％、（36．7±14．2）％及（52．3±22．8）％，各组间差异有统计学意义。浆液性卵巢癌高、中及低分化组织MVD值分别为18．3±3．4、24．2±3．1及32．3±6．4，VEGF的表达分别为（30．9±16．2）％、（48．0±18．4）％及（62．1±21．3）％，各组间差异有统计学意义。浆液性卵巢癌FIGOⅢ～Ⅳ期及Ⅰ～Ⅱ期的MVD值分别为28．9±4．7及22．0±4．7，VEGF的表达分别为（55．1±22．9）％及（40．18±18．0）％，差异均有统计学意义。浆液性卵巢癌中VEGF的表达与肿瘤组织中的MVD值呈正相关关系（r=0．576）。结论血管生成在浆液性卵巢肿瘤的发生、发展中起重要促进作用。Objective To study the angiogenesis in serous ovarian neoplasms. Methods Immunohistoehemical method was used to examine microvessel density （MVD） and the expressions of vascular endothelial growth factor （VEGF） in 76 cases of serous ovarian neoplasm. The relationship between MVD and VEGF were investigated. Results MVD in the tissues of cystadenoma, bordline cystadenoma and cystadenoeareinoma were 7.8±2.4, 17.5 ±3.3 and 27.6±7.5; VEGF expressions were （16.1 ± 3.9）0/0, （36.7± 14.2）%o, （52.3±22.8）%; the differences were significant respectively. Of cystadenocarcinoma grade 1, grade 2 and grade 3, MVD were 18.3±3.4, 24.2±3.1, and 32.3±6.4, VEGF expressions were （30.9±16.2）%, （48.0± 18.4） %0 and （62.1±21.3） %, the differences were significant respectively. Of FIGO stage Ⅲ-Ⅳ and stage Ⅰ-Ⅱ, MVD were 28.9 ± 4.7 and 22.0±4.7, VEGF expressions were （55.1±22.9） % and （40.18±18.0） %, the differences were significant respectively. There was significant positive correlation between VEGF expression and MVD, Conclusion Angiogenesis is very important in the development of serous ovarian neoplasms.

关 键 词：卵巢肿瘤 血管内皮生长因子类 微血管密度 

分 类 号：R737[医药卫生—肿瘤]