可生物降解载药性晶状体囊袋张力环抑制后发性白内障的研究进展  

Study of biodegradable drug-sustained capsular tension ring in preventing posterior capsule opacification

作　　者：赵玉新[1] 吴明星[1] 

机构地区：[1]眼科学国家重点实验室、中山大学中山眼科中心,广东省广州市510060

出　　处：《眼科新进展》2009年第1期61-65,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:30572003)~~

摘　　要：后发性白内障(posterior capsule opacification,PCO)是白内障摘出联合后房型人工晶状体植入术后导致视力下降的最常见远期并发症,是术后残留晶状体上皮细胞增生、迁移、上皮-间质转化,以及术后创伤和炎症反应的结果。术中植入含抑制晶状体上皮细胞增生药物的缓释系统或囊袋张力环均有可能降低PCO的发生。本文就药物、缓释系统、囊袋张力环在预防PCO中的应用加以综述,并构想一种可生物降解载药性晶状体囊袋张力环来预防PCO。Posterior capsule opacification （PCO）-induced decreased visual acuity, is the main long-term complication following the cataract extraction with posterior chamber intraocular lens implantation. PCO is caused by the proliferation, migration, and epithelial-mesenchymal transition of the retaining lens epithelial cells,also results from the traumatic and inflammatory reaction. Implanting the drug-sustained delivery system or capsular tension ring in the cataract surgery may reduce PCO. We summarize the application of drugs, drug-sustained delivery system and capsular tension ring in preventing PCO. Furthermore, to develop a biodegradable drug-sustained capsular tension ring to prevent PCO may be effective and safe.

关 键 词：缓释系统 囊袋张力环 后发性白内障 

分 类 号：R776.1[医药卫生—眼科]