脂蛋白脂酶基因多态性与缺血性脑卒中的相关性研究  

Association study of lipoprotein lipase gene polymorphisms with acute ischemic stroke

作　　者：杨玉梅[1] 吴江[1] 杜丹华[1] 高鹏[2] 王凤[1] 

机构地区：[1]吉林大学第一医院神经内科,吉林长春130021 [2]吉林大学第一医院内分泌科,吉林长春130021

出　　处：《中国老年学杂志》2009年第2期193-194,共2页Chinese Journal of Gerontology

基　　金：吉林省科技厅资助项目(No.20060413-1);长春市科技局资助项目(No.2006070)

摘　　要：目的探讨脂蛋白脂酶(LPL)基因多态性与缺血性脑卒中发病的相关性。方法选择600例缺血性脑卒中患者和419例对照组人群,以位于LPL基因的PLR-rs326位点为遗传标记,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测LPL基因的多态性。结果病例组GG基因型频率明显高于对照组(P<0.05);动脉粥样硬化性脑梗死组G变异等位基因频率与对照组相比差异显著。结论LPL rs326位点基因多态性与缺血性脑卒中的发病相关。Objective To investigate the association between lipoprotein lipase （LPL） rs326 polymorphism and ischemic stroke. Methods A case-control study of 1 019 subjects was performed including 600 acute ischemic stroke patients and 419 controls. LPL rs326 genotypes were determined by PCR-RFLP. Results The frequency of GG genotype of rs326 was significantly higher in patients group than that in control group （P 〈0. 05）. 600 patients were divided into cerebral thrombosis infarction group and lacunar infarction group, and the distribution of LPL rs326 G allete was different significantly between cerebral thrombosis infarction group and control group. Conclusions LPL rs326 polymorphism is associated with the pathogenesy of cerebral thrombosis infarction.

关 键 词：脑梗死 脂蛋白脂酶基因 单核苷酸多态性 

分 类 号：R743.2[医药卫生—神经病学与精神病学]