地榆升白片预防非小细胞肺癌患者化疗后外周血细胞下降的临床研究  

Effect of Diyushengbai Tablet on Blood Cell Decreasing During Chemotherapy of Non-small Cell Lung Cancer

作　　者：董颖[1] 黄建瑾[1] 

机构地区：[1]浙江大学医学院附属二院肿瘤科,浙江杭州310009

出　　处：《华西医学》2009年第1期64-66,共3页West China Medical Journal

摘　　要：目的:观察地榆升白片对非小细胞肺癌化疗后外周血细胞的影响,以了解地榆生白片对骨髓的保护作用。方法:将63例非小细胞肺癌患者随机分为观察组和对照组。观察组(33例)采用地榆升白片加NP方案治疗,对照组(30例)单用NP方案化疗,观察两组外周血象变化情况及集落刺激因子(G-CSF)用量。结果:观察组Ⅲ度及Ⅳ度骨髓抑制发生率9.09%,显著低于对照组(对照组为30.0%,χ2=4.467,P<0.05);观察组外周血WBC、PLT、Hb治疗结束后1月与治疗前相比,差异无统计学意义,P>0.05;对照组外周血WBC、PLT、Hb治疗结束后1月较治疗前明显下降,其中WBC、PLT差异有统计学意义,P<0.05。观察组和对照组人均集落刺激因子(惠尔血150μg)用量分别为(0.58±1.99)支和(1.93±3.62)支差异有统计学意义(t=2.501,P<0.05)。结论:地榆升白片可预防肺癌患者化疗药物引起的骨髓抑制,提高外周血WBC和PLT水平,减少集落刺激因子的用量,值得推广。Objective：To observe the effects of Diyushengbai tablet（DY） on blood cell decrease in chemotherapy of non-small cell lung cancer（NSCLC）. Methods： Sixty three patients with NSCLC were randomized into two groups：observational group（33 patients, NP＋ DY） and control group（30 patients, NP only）. The myelosuppression level and the quantity of granulocytic colony stimulating factor（G-CSF） being used were investigated. Results：The rate of Ⅲ and Ⅳ myelosuppression was 9.09 % in observational group was significant lower than in control group of 30.0% （= 4. 467, P =0.05）. There was no difference of statistical significance in the number of peripheral blood WBC, PLT and Hb treat- ment after the end of 1 month compared with before treatment in observatinal group （P〉0.05）. The peripheral blood WBC, PLT and Hb decreased obviously after treatment of 1 month than before treatment in control group. Among them, the WBC and PLT had significant differences,P〈0.05. The quantity of colony stimulating factor （150μg） being used in observational group and in control group were 0.58± 1.99 and 1.93±3.62 respectively and it had a significant difference with P〈.05. Conclusion：DY can decrease bone marrow suppression caused by chemotherapy in NSCLC patients, raising the level of peripheral blood WBC and PLT,reduce the using amount of colony stimulating factor （G-CSF）. It is worth promoting.

关 键 词：非小细胞肺癌 地榆升白片 化疗 骨髓抑制 

分 类 号：R734.2[医药卫生—肿瘤]