不同肝病者外周血sIL-2R的检测及意义  

DETERMINARION AND SIGNIFICANCE OF SOLUBLE INTERLEUKIN2 RECEPTOR IN PATIENTS WITH DIFFERENT LIVER DISEASES

作　　者：张世能[1] 陈伟强[1] 袁世珍[1] 朱兆华[1] 王连源[1] 黄志清[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院

出　　处：《中山医科大学学报》1998年第2期147-149,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：目的：探讨几种肝病患者外周血可溶性白细胞介素２受体（ｓＩＬ２Ｒ）水平状态及其临床意义。方法：采用双抗体夹心ＥＬＩＳＡ法检测慢性乙型肝炎、肝硬化和原发性肝癌患者（共７０例）与健康人（２２例）的外周血ｓＩＬ２Ｒ水平，并比较原发性肝癌（１５例）手术前后ｓＩＬ２Ｒ水平的变化。结果：与对照组相比，慢性乙型肝炎、肝硬化和原发性肝癌患者的ｓＩＬ２Ｒ水平明显增高；肝癌术后ｓＩＬ２Ｒ水平明显下降；ｓＩＬ２Ｒ水平与肝癌临床分期相关。结论：进一步证实血清ｓＩＬ２Ｒ水平可间接反映几种肝病的细胞免疫功能状态。Objective:To explore the changes of serum sIL2R level in patients with different liver diseases and to evaluate its potential value in clinical application.Method: Serum sIL2R level was measured with ELISA assay in 70 patients with different liver diseases and 22 healthy persons.Results:Serum sIL2R level in hepatic patients was significantly higher than those in normal controls. The serum sIL2R level of patients with primary hepatic carcinoma was lowered after surgery. There was a positive relationship between the serum sIL2R level and the stage of the carcinoma. Conclusion:It is suggested that determing the serum sIL2R levle may be of obvious value to monitoring these patient's cellular immunity condition.

关 键 词：肝肿瘤 免疫学 受体 白细胞介素2 

分 类 号：R735.703[医药卫生—肿瘤]