脑原发淋巴瘤8例综合治疗分析  

Analysis of combined therapy for primary cerebral lymphoma

作　　者：马剑波[1] 施健[1] 季斌[1] 陈不尤[1] 

机构地区：[1]南通大学附属医院放疗科,南通226001

出　　处：《中国肿瘤临床与康复》2008年第6期519-521,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的分析脑原发淋巴瘤的临床特点,探讨其治疗方式。方法8例脑原发淋巴瘤中7例行手术切除,1例行立体定向活检。8例均行放射治疗,1例接受γ刀治疗,7例6MV X线常规分割照射,全脑照射30～46 Gy,病灶区剂量40～56 Gy。6例接受了化疗,行CHOP方案4例,大剂量甲氨蝶呤(MTX)为主的化疗2例,鞘注MTX 3例。结果患者近期疗效好,全组生存时间为8～47个月,中位生存期19个月。1、3年生存率分别为75.0%和31.3%。加化疗未延长生存期,予MTX化疗者生存时间较长。结论脑原发淋巴瘤预后差,全脑放疗为主要治疗方式之一,放疗与MTX为主的化疗方案的综合治疗有可能提高疗效。Objective To analyse the clinical characteristics and explore the therapeutic option of primary cerebral lymphoma. Methods Eight patients with primary cerebral lymphoma were treated between January 1999 and May 2006. Seven cases were treated with surgical resection and one case received biopsy. One case received stereotactic radiosurgery（γ-knife） ,7 cases received cranial radiotherapy（30-46 Gy whole brain plus 10-20 Gy boost）. Six patients received chemotherapy. Of them, 4 received CHOP regimen,2 received high-dose MTX, 3 received intraventricular MTX. Results The short-term response rate to therapy was high, the median survival time was 19 months （ range, 8-47 months）, the 1-, 3-year survival rates were 75. 0% and 31.3%. The survival time in the patients receiving MTX was longer than that in patients receiving CHOP. Conclusions The prognosis of primary cerebral lymphoma is poor. The whole brain irradiation is one of the important treatment methods. Combined therapy based on high-dose MTX may improve the survival time in primary cerebral lymphoma.

关 键 词：非霍奇金淋巴瘤/放射疗法 非霍奇金淋巴瘤/化学疗法 

分 类 号：R739.4[医药卫生—肿瘤]