P-gp、GST-π和C-erbB-2在乳腺癌中的表达及其临床意义  

Expressions and Clinical Significance of P-gp,GST-π and C-erbB-2 in Breast Cancer

作　　者：孙浩[1] 于晓东[2] 

机构地区：[1]重庆市第三人民医院普外科,重庆400014 [2]重庆市第三人民医院病理科,重庆400014

出　　处：《中国普外基础与临床杂志》2009年第1期56-59,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨乳腺癌组织中P-糖蛋白(P-gp)、胎盘型谷胱甘肽-S-转移酶-π(GST-π)和人表皮生长因子受体2(C-erbB-2)蛋白的表达与临床病理特征和预后的关系。方法采用免疫组化法检测48例乳腺癌组织中P-gp、GST-π和C-erbB-2蛋白表达,并对其临床病理特征和患者5年生存率进行综合分析。结果P-gp和GST-π蛋白表达与乳腺癌患者年龄、组织学分级、转移淋巴结数和TNM分期无关(P>0.05);而C-erbB-2蛋白表达与乳腺癌组织学分级、转移淋巴结数和TNM分期有关(P<0.05)。P-gp表达阳性率在C-erbB-2表达阳性的乳腺癌中显著高于C-erbB-2表达阴性的乳腺癌(P<0.05);5年内生存者的GST-π和C-erbB-2表达阳性率明显低于5年内死亡者(P<0.01)。结论P-gp参与乳腺癌的原发耐药机理,C-erbB-2表达阳性的乳腺癌发生原发性耐药的可能性较大,C-erbB-2是评估乳腺癌预后和预测治疗效果的指标。Objective To investigate the relationship between the expressions of P-gp, GST-π and C-erbB-2 and clinicopathologie characteristics as well as prognosis in breast cancer. Methods The expressions of P gp, GST- π and C-erbB-2 were detected by immunohistochemistry in 48 cases of breast cancer, and histopathologic characteristics as well as 5-year survival rate of these cases were analyzed. Results There was no significant difference in the expressions of P-gp and GST-π with age, histologic grade, number of lymph node metastasis and TNM stage of breast cancer （P〉0.05）. There was significant difference in expression of C-erbB-2 with histologic grade, number of lymph node metastasis and TNM stage of breast cancer （P〈0. 05）. Positive rate of P gp expression in breast cancer with positive C-erbB-2 expression was remarkably higher than that in breast cancer with negative C-erbB-2 expression （P〈0.05）. Positive rate of GST-π and C-erbB-2 expression in survivals within 5 years was remarkably lower than that in deaths within 5 years （P〈0.01）. Conclusion P gp participates primary drug-resistance mechanism of breast cancer. The possibility of primary drug-resistance is higher in breast cancer with positive C-erbB-2 expression. The expression of C-erbB-2 helps to evaluate prognosis and the result of treatment in breast cancer.

关 键 词：乳腺癌 P-糖蛋白 胎盘型谷胱甘肽-S-转移酶-π 人表皮生长因子受体2 预后 

分 类 号：R737.9[医药卫生—肿瘤]