急性淋巴细胞白血病患儿肝功能损害相关因素分析及治疗  

Correlated factors and treatment of liver injury in children with acute lymphoblastic leukemia

作　　者：杨静[1] 孙立荣[2] 

机构地区：[1]青岛大学,山东青岛266003 [2]青岛大学医学院附属医院

出　　处：《山东医药》2008年第44期7-9,共3页Shandong Medical Journal

摘　　要：目的分析急性淋巴细胞白血病(ALL)患儿肝功能损害原因,指导临床治疗。方法对124例ALL患儿于化疗不同阶段进行肝功能和病毒学检测,对引起肝功能损伤的原因、损害程度及保肝治疗效果进行分析。结果124例患儿中58例发生肝功能损害,其中药物性损害发生率(70.69%)明显高于病毒性及白血病浸润性损害,以病毒性损害程度最重,以大剂量甲氨喋呤(HDMTX)庇护所防治期最常见;经复方甘草酸单胺、还原性谷胱甘肽及相应抗病毒治疗后,各组谷草转氨酶和谷丙转氨酶均恢复正常,病毒性损害恢复时间最长。结论针对ALL肝损害病因进行治疗可促进肝功能恢复,利于化疗顺利进行。Objective To investigate the cause and treatment of the liver injury in children with acute lymphoblastie leukemia（ALL）. Methods Hepatic function and index of virus in 124 patients with ALL were examined during various stages of chemotherapy. Pathogeny and degree of liver injury and the effect of treatment were analyzed. Results Hepatic function of 58 cases were abnormal, the occurrence rate of drug induced liver injury was higher than that of virus induced liver injury and liver invasion. Liver injury caused by HDMTX were found with the highest frequency. AST and ALT of 58 children descended after treated by poterdin and reduced glutathione for （5 ±2.3） days,and the recovery time of virus in- duced liver injury was the longest. Conclusion To treat the liver injury in cases with ALL according to pathogeny can accelerate the recovery of hepatic function.

关 键 词：急性淋巴细胞白血病 肝功能 损伤 

分 类 号：R733.71[医药卫生—肿瘤] R575[医药卫生—临床医学]