硫普罗宁联合化疗治疗晚期乳腺癌的临床观察  

Protective effect of liopronin supplemented with chemotherapy in treating advanced breast cancer

作　　者：陈焕伟[1] 赵小琼[1] 冯仙明[1] 凌华海[1] 

机构地区：[1]广东省农垦中心医院肿瘤三区,广东省湛江524003

出　　处：《中国基层医药》2008年第11期1825-1826,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察硫普罗宁联合化疗治疗晚期乳腺癌的疗效及安全性。方法60例晚期乳腺癌患者随机分为治疗组28例和对照组32例，两组化疗方案均为长春瑞滨＋顺铂，治疗组加用硫普罗宁，疗程10d，观察两组临床疗效及不良反应发生情况。结果治疗组有效率为46．4％，对照组为46．9％，差异无统计学意义（P〉0．05）。治疗组KPS评分下降率17．9％，明显低于对照组的43．8％，两组间差异有统计学意义（P〈0．05）。治疗组肝功能损害率（9．4％）及白细胞下降率（46．4％）明显低于对照组（31．2％、81．2％）（P〈0．05、P〈0．01）。结论硫普罗宁能降低晚期乳腺癌患者化疗的不良反应，改善了患者的生存质量，且不影响化疗的疗效，值得临床推广应用。Objective To observe the efficacy and safety of tiopronin supplemented with chemotherapy in treating advanced breast cancer. Methods Sixty patients with advanced breast cancer were randomly divided into two groups ： treatment group（ n = 28 ） and control group （ n = 32 ）. Two groups were treated the same of NVB ＋ DDP, the treatment group was supplemented with tiopronin,given for 10 days. Efficacy,toxicity in two groups were compared. Results The effective rate in the treatment group and the control group were 46. 4% and 46. 9% respectively, with no significant difference between the two groups ,P 〉 0. 05. But the improved quality of life of patients in the treatment group was higher than that in the control group, P 〈 0. 05. The rate of adverse reaction in liver function damaged （ 9. 4% ） and leucocyte lassitude（46. 4% ） were apparent lower than those in the control group（ 31.2% ,81.2% ） , with significant difference between the two groups （ P 〈 0. 05, P 〈 0. 01 ）. Conclusion Tiopronin supplemented with chemotherapy show apparent effect in decreasing the adverse reaction of chemotherapy, improving the quality of life and not influence efficacy in advanced breast cancer. So tiopronin may act as protective drug for chemotherapy and deserve further testing in the clinic.

关 键 词：乳腺肿瘤 抗肿瘤联合化疗方案 硫普罗宁 

分 类 号：R737[医药卫生—肿瘤]