胃癌模糊基因调控网络的构建  

Construction of Fuzzy Gene Regulatory Networks In Gastric Carcinoma

作　　者：黄成玉[1,2] 阮晓钢[1] 李建更[1] 

机构地区：[1]北京工业大学电子信息与控制工程学院,北京100022 [2]华北科技学院电子信息工程系,北京东燕郊101601

出　　处：《微计算机信息》2008年第36期14-16,共3页Control & Automation

基　　金：国家自然科学基金委(60234020);项目名称:复杂系统意义下生物信息学中若干重大问题的研究;基金申请人:阮晓钢

摘　　要：基因调控网络的研究是以系统的观点为出发点,从基因之间相互作用的角度揭示复杂的生命现象。生命体通过调节差异基因表达来控制其生长、遗传和变异行为。差异表达基因之间的相互作用是构建基因调控网络的纽带,网络中差异表达的基因可以揭示与癌症相关基因的信息。基因网络模型为深入理解生命本质提供了有益的参考,本文提出了一种新颖的方法来预测基因调控网络,即将模糊理论引入基因网络的构建中,阐述了模糊理论基因调控网络建模的机理并初步建立了胃癌模糊基因调控网络,对研究胃癌的发生和发展机理有重要的理论意义和应用价值。The study of gene regulatory networks is based on the viewpoint of system,and reveals the life phenomena by the interac-tion between genes. The individual controls growth,inheritance and aberrance behavior by regulating different gene expressions. Gene regulatory networks are connected with the interaction between different gene expressions,meanwhile different gene reveals the gene information of cancer. Gene networks model is helpful to understanding life. In this paper,a novel method to forecast gene regulatory networks is put forward,namely fuzzy theory is introduced to gene regulatory networks. The principles of gene regulatory networks based on fuzzy theory are explained and the gene regulatory networks in gastric carclnoma are established. The method is important in studying the growth and development of gastric carcinoma.

关 键 词：模糊控制 基因调控网络 差异表达基因 

分 类 号：Q81[生物学—生物工程]