小鼠急性重复缺氧对脑神经节苷脂的影响  

The Effect of Gangliosides and Animal Protecting Effect in Acute and Repetitive Hypoxia

作　　者：潘颖[1] 杨典洱[1] 于培兰[1] 

机构地区：[1]首都医科大学生物化学教研室

出　　处：《首都医科大学学报》1998年第1期9-12,共4页Journal of Capital Medical University

摘　　要：利用重复缺氧的方法，研究小鼠间歇性低氧适应和神经节苷脂（Ｇｌｓ）的作用。发现：在小鼠急性缺氧时，血液和脑组织中的谷胱甘肽过氧化物酶（ＧＳＨｐｘ）活性明显下降（Ｐ＜０．０１）；脑组织中的ＧＳＨｐｘ活性在急性重复缺氧时较１次缺氧时升高（Ｐ＜０．０５）；脑组织的Ｇｌｓ含量明显下降（Ｐ＜０．０１）。提示Ｇｌｓ和ＧＳＨｐｘ有相同的抗自由基活性。急性重复性缺氧时Ｇｌｓ下降，去甲肾上腺素（ＮＥ）也下降（Ｐ＜０．０１），不同于持续性低氧的表现。推测脑细胞β受体腺苷酸环化酶系统在急性重复缺氧时未受严重伤害，Ｇｌｓ和缺氧、缺氧保护有关。epetitive hypoxia method was used to study the adaptation of mice to intermittent hypoxia and the effect of gangliosides. The activity of GSHpx was decreased (P<0.01), not only in blood but also in brain. Under acute repetitive hypoxia for 4 times, the activity of GSHpx in brain was increased (P<0.05) as compared with that under the hypoxia for one time. At that time, the gangliosides in the membrane of brain cell were decreased (P<0.01). It showed that Gls and the activity of GSHpx were interrelated. The contents of norepinephrine in brain were lower than the controls (P<0.01). The results indicated that the system of β receptor adenyl cyclase was not injured by acute and repetitive hypoxia.

关 键 词：急性缺氧 重复缺氧 神经节苷脂 GSHPX 缺氧 

分 类 号：R364.4[医药卫生—病理学] Q593.2[医药卫生—基础医学]