癌基因p21^(pan-ras)和p62^(c-myc)在皮肤T细胞淋巴瘤中的表达及其意义  

EXPRESSION OF ONCOPROTEIN p21panras ANDp62c-myc IN CUTANEOUS T CELL LYMPHOMA AND ITS SIGNIFICANCE

作　　者：白亚来[1] 张春雷[1] 尹善雪[1] 沈力[1] 李世荫[1] 

机构地区：[1]北京医科大学第三医院皮肤科

出　　处：《北京医科大学学报》1998年第1期24-25,45,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：研究癌基因在皮肤Ｔ细胞淋巴瘤中的作用。方法：采用免疫组织化学技术检测了３２例蕈样肉芽肿／Ｓéｚａｒｙ综合征（ＭＦ／ＳＳ）皮肤组织中癌基因ｒａｓ和ｍｙｃ蛋白产物ｐ２１和ｐ６２的表达。结果：３２例ＭＦ／ＳＳ中有１２例ｐ２１阳性，有１７例ｐ６２阳性，有１０例同时示ｐ２１和ｐ６２阳性。其中有皮肤外播散的进展期ＭＦ／ＳＳ比局限于皮肤的早期ＭＦ／ＳＳ增高明显。结论：ｐ２１ｐａｎｒａｓ和ｐ６２ｃｍｙｃ的表达，与ＭＦ／ＳＳ细胞增殖转化相关。ｒａｓ和ｍｙｃ癌基因可能在ＭＦ／ＳＳ的多阶段发病过程中起协同作用。Objective:To study the role of the oncogenes in cutaneous T cell lymphoma. Methods:Immunohistochemical technique was used to detect the expression of p21panras and p62c-myc in skin tissue sections of 32 mycosis fungoides/sézary syndrome(MF/SS). Results: The expression of p21 and p62 was seen in 12/32 and 17/32 MF/SS respectively. Increased detection of both p21 and p62 in atypical lymphoid cells was seen in advanced stages of MF/SS as compared with early MF/SS respectively. Conclusion: The expression of p21 and p62 is related to the degrees of proliferation and transformation of tumor cells in MF/SS.They may play a coordinated role through the multi-step　lymphomagenesis in MF/SS.

关 键 词：皮肤肿瘤 T细胞淋巴瘤 癌基因 P21 基因表达 

分 类 号：R739.5[医药卫生—肿瘤]