髓母细胞瘤中间丝蛋白及神经内分泌标志物表达的研究  

A STUDY OF EXPRESSION OF INTERMEDIATE FILAMENT PROTEINS AND NEUROENDOCRINE MARKERS IN MEDULLOBLASTOMA

作　　者：张庆慧[1] 李红[1] 梁思泰[1] 孙鸿钺 谭燕泉[1] 苏晓萍[1] 

机构地区：[1]山东医科大学病理解剖学教研室

出　　处：《山东医科大学学报》1998年第2期91-95,共5页Acta Academiae Medicinae Shandong

基　　金：国家自然科学基金

摘　　要：采用免疫组化ＡＢＣ法对８２例髓母细胞瘤（ＭＢ）进行中间丝蛋白（ＧＦＡＰ、ＮＦ、Ｖｉｍ）和神经内分泌标志物（ＳＹＮ、ＣｇＡ）检测。结果显示ＭＢ８２例中，ＧＦＡＰ阳性７４例（９０．２４％）、ＮＦ阳性１７例（２０．７３％）、Ｖｉｍ阳性３３例（４０．２４％）、ＳＹＮ阳性６２例（７５．６１％）、ＣｇＡ阳性２２例（２６．８３％）。有８例肿瘤５种标志物均有表达，其余也有２种或２种以上标志物表达。标志物表达与患者年龄、性别、肿瘤大小、分化及预后等因素之间无关（Ｐ皆＞０．０５）。提示髓母细胞瘤是具有不同中间丝蛋白及神经内分泌标志物表达的异质性肿瘤。这种表达可能是幼稚的原始神经外胚层组织胚胎发育过程中标志物表达的重演。Eighty two cases of medulloblastoma(MB)were studied with monoclonal antibodies to glial fibrillary acidic protein(GFAP),neurofilament(NF),vimentin(Vim),synaptophysin(SYN),chromgraninesA(CgA) by use of immunohistochemical ABC technique.The results showed that the percentage of positivity were GFAP 90.24%(74/82),NF 20.73%(17/82),Vim 40.24%(33/82),SYN 75.61%(62/82),CgA 26.83%(22/82).All MB in this study showed convincing coexpression of two or more kinds of markers.No correlation was found between the marker expression with the sex,age,size,differentiation and prognosis of MB.It is concluded that MB is a tumor arising from the primitive neuroectodermal cells with multipotential differentiation.The tumor cells are capable of both neuronal and glial differentiation and in some cases they seem to have neuroendocrine function as well.

关 键 词：髓母细胞瘤 胞浆丝 神经内分泌 丝蛋白 表达 

分 类 号：R730.264[医药卫生—肿瘤]