上海松江区结直肠癌普查研究的初步结果  

A survey of colorectal cancer among asymptomatic population in Songjiang district of Shanghai

作　　者：朱小英[1] 孙波 董雄伟[1] 黄江[1] 杨小娟[1] 孙四云 朱美英 

机构地区：[1]上海市松江区中心医院内镜中心,201600 [2]百汇医疗集团(中国及北亚区)消化科 [3]上海市松江区新浜镇社区卫生服务中心 [4]上海市松江区卫生局疾控卫生中心

出　　处：《中华消化内镜杂志》2009年第1期32-34,共3页Chinese Journal of Digestive Endoscopy

摘　　要：目的探讨粪便隐血试验结合大肠镜检查作为大肠癌普查方式的可行性。方法2006年9月至2007年5月，对上海市松江区无症状且结直肠癌普通危险度的≥50岁人群以及40～49岁志愿参加普查者行免疫组化法粪便隐血试验，连续3次排便中任意2次粪便标本送检，对任何1次粪便隐血阳性（包括弱阳性）的患者行全结肠镜检查。对息肉的数量、分布位置及病理结果进行统计。结果≥50岁受检者共2692例，粪便隐血试验阳性者184例，阳性率6．8％，共56例患者发现了64枚结肠息肉，包括腺瘤性息肉34枚、炎性息肉15枚、增生性息肉15枚，发现直肠癌1例。40～49岁志愿普查者共582例，隐血试验呈阳性者28例，阳性率4．8％，共6例患者发现了6枚息肉，包括腺瘤性息肉1枚、炎性息肉5枚，并发现肠癌2例。多数息肉分布于左半结肠。结论对无症状的结直肠癌普通危险度人群的普查能较早发现结肠息肉，对粪便隐血试验阳性的患者行全结肠镜检查可能较适合社区及广大农村地区结直肠癌的大规模普查。Objective To evaluate the feasibility of fecal occult blood test （ FOBT）, combined with colonoseopy, in screening of coloreetal cancer. Methods From September 2006 to May 2007, healthy vol- unteers without any colorectal cancer （CRC） related symptoms in Songjiang District of Shanghai, aging from 40 to 49 or older than 50 years, were recruited. The subjects were firstly screened by FOBT with immunohis- tochemical method in two of three consecutive stool samples, and colonoscopy was performed in those with positive FOBT in any of the stool samples. The number, type and distribution of detected polyps were recor- ded. Results Of 2692 subjects over 50 years old, FOBT was positive in 184 （6. 8% ）, in which 1 rectal cancer and 64 polyps, including 34 adenomatous polyps, 15 inflammatory polyps and 15 hyperplastic polyps. Of 582 subjects aging from 40 to 49 years, FOBT was positive in 28 （4. 8% ） , in which 2 adenocarcinoma and 6 polyps, including 1 adenomatous polyp. Most polyps, including adenomatous polyp and high-risk pol- yp, were mainly found on the left side of colon. Conclusion CRC screening with FOBT and colonoscopy in asymptomatic average-risk people could detect colon polyps at an early stage. Colonoscopy in patients with positive FOBT would be suitable in large scale CRC screening in communities and rural areas.

关 键 词：结直肠肿瘤 普查 潜血 结肠镜检查 

分 类 号：R735[医药卫生—肿瘤]