ERCC1、ERCC2的多态性对常见消化系统肿瘤的影响  

The Influence on the Single Nucleotide Polymorphisms of ERCC1,ERCC2 to the Digestive System Cancers

作　　者：张慧[1] 刘巍[1] 王淑琴[1] 

机构地区：[1]河北医科大学附属第四医院肿瘤内科

出　　处：《医学综述》2009年第3期327-331,共5页Medical Recapitulate

摘　　要：机体DNA修复系统如核苷酸切除修复在维持基因组功能整体性、修复致癌因素所致的损伤及抗癌过程中有着重要作用。一些核酸修复基因，如切除修复交叉互补基因1（ERCC1）及人类着色性干皮病基因D（XPD／ERCC2）的水平下降，可能会成为某种或某几种肿瘤的易感因素；但如果此种基因的水平较高，修复损伤的能力提高，对化疗药物所致基因损伤的修复能力也就增强了，那么可能对化疗药物产生耐药现象。以上两种基因的单核苷酸多态与以DDP、5-FU为基础的化疗方案的疗效存在一定关系，而消化道肿瘤又多应用铂剂及5-FU治疗，故本文对ERCC1、XPD／ERCC2与几种常见消，匕道肿瘤的发生及其化疗疗效的关系予以综述。DNA repair Organism such as nucleotide excision repair which have an important role in the maintenance of genome integrity, repairing damage caused by cancer-causing factors and the anticancer process. A number of nucleic acid repair genes such as excision repair cross-complementing gene 1 （ ERCC1 ） and human xeroderma pigmentosum gene D（ XPD/ERCC2 ）, the level descent may be susceptible factors to one or certain kinds of tumors; but if these genes＇ level are higher,the ability to repair damage and chemotherapy-induced genetic damage will be enhanced,it may be resistance to chemotherapeutic drugs. The single nucleotide polymorphisms of the two genes have certain relationship with DDP,5-FU-based chemotherapy efficacy, and more application of gastrointestinal cancer use platinum agents and 5-FU treatment, so this paper will summarize the relationship of occurrence and effect between ERCC1, XPD / ERCC2 and several common gastrointestinal cancer.

关 键 词：切除修复交叉互补基因1 人类着色性干皮病基因D 单核苷酸多态 化疗 

分 类 号：R735[医药卫生—肿瘤]