慢性丙型肝炎和糖尿病相关性研究进展  

The Research Progress of Chronic Hepatitis C and Diabetes Mellitus

作　　者：郝蔚[1] 苏少慧[1] 甄承恩[1] 

机构地区：[1]河北省人民医院消化科

出　　处：《医学综述》2009年第3期443-446,共4页Medical Recapitulate

摘　　要：肝脏在血糖代谢中起重要作用，各种导致慢性肝实质损害的慢性肝病均可影响正常的糖代谢，甚至可出现糖耐量减退或糖尿病。近年来有很多流行病学调查证实了慢性丙型肝炎与糖尿病有密切的相关性，慢性丙型肝炎的患者中糖尿病的患病率明显高于普通人群和其他原因所致的慢性肝病患者，其发病机制可能与胰岛素抵抗、自身免疫、丙型肝炎病毒肝外复制等有关，其中胰岛素抵抗为最主要发病机制，肿瘤坏死因子α在丙型肝炎病毒相关的胰岛素抵抗中起着重要的作用。The liver plays an important role in glucose metabolism, chronic liver parenehyma lesion eaused by various chronic hepatopathy can affect the normal glycogen metabolism, even can lead to impaired glucose tolerance or diabetes mellitus. Recently, several epidemiologie studies have eonfirmed the link between ehmnie hepatitis C and diabetes mellitus. The prevalence of diabetes mellitus for the patients with chronic hepatitis C virus（HCV） infection is obviously higher than those in healthy person and patients with other chronic hepatitis patients due to other reasons. The possible pathogenesis maybe related to autoimmune, HCV replication out of the liver,and insulin resistance that is the main factor and so on. The tumor necrosis faetor （TNF）-α might react greatly on insulin resistance relevant to HCV infection.

关 键 词：慢性丙型肝炎 糖尿病 胰岛素抵抗 肿瘤坏死因子Α 

分 类 号：R575.11[医药卫生—消化系统] R587.1[医药卫生—内科学]