乙酰肝素酶在乳腺浸润性导管癌中的表达及其意义  

Expression of heparanase in invasive ductal carcinomas of the breast and its significance

作　　者：郑晓东[1] 毛大华[2] 

机构地区：[1]重庆市肿瘤研究所乳腺科,400030 [2]贵阳医学院附属医院乳腺科,贵州贵阳550004

出　　处：《蚌埠医学院学报》2009年第1期30-32,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨乙酰肝素酶(Hpa)在乳腺浸润性导管癌发展过程中的作用及其临床意义。方法:采用免疫组织化学法检测Hpa在14例乳腺纤维腺瘤和81例乳腺浸润性导管癌中的表达,分析其与乳腺浸润性导管癌临床病理参数的关系。结果:在乳腺浸润性导管癌组中Hpa的阳性表达率为72.96%,显著高于在乳腺纤维腺瘤组中的表达(P<0.005);Hpa表达与肿瘤的组织学分级、肿瘤最大径、PTNM分期、淋巴结转移均有一定关系(P<0.005),而与患者的年龄、月经状况均无明显关系(P>0.05)。结论:Hpa可能促进乳腺浸润性导管癌的生长、浸润和转移,并在一定程度上标志着肿瘤的生物学特征。Objective ：To study the role and clinical significance of heparanase（Hpa） in the progress of invasive ductal carcinomas of the breast. Methods： Hpa expression in 14 cases of fibroadenomas and 81 cases of invasive ductal carcinomas of the breast was examined by PV-9000 immunohistochemistry analysis. Its correlation with clinic-pathological parameters in the carcinomas of the breast was also studied. Results：The positive expression ratio of Hpa in the tissues of invasive ductal carcinomas of the breast was 72.96%, which was significantly higher than that in fibroadenomas（P 〈 0.005 ） ;Hpa expression was correlated with tumor＇s size, pTNM stage, histological grade and lymph node metastasis （P 〈 0. 005 ）, but was not significantly correlated with patients＇ menstruation status or age （ P 〉 0.05 ）. Conclusions ： Hpa may accelerate the growth, invasion and metastasis of carcinomas of the breast. It reflects the biological characteristics of carcinomas of the breast to some degree.

关 键 词：乳腺肿瘤 乙酰肝素酶 免疫组织化学 肿瘤转移 

分 类 号：R737.9[医药卫生—肿瘤] R392.31[医药卫生—临床医学]