有机锡(Ⅳ)配合物{[(n-C4H9)2Sn(0．5·O2CCH2C12H8N)(0．5·C2H5O)]2O}2·(C12H8NH)的合成、结构和抑瘤活性  

Synthesis,Crystal Structure and Antitumor Activity of Organotin(Ⅳ) Complex {[(n-C_4H_9)_2Sn(0.5·O_2CCH_2C_(12)H_8N)(0.5·C_2H_5O)]_2O}_2·(C_(12)H_8NH)

作　　者：高中军[1] 刘广军[1] 尹汉东[2] 

机构地区：[1]济宁学院化学系,曲阜273155 [2]聊城大学化学化工学院,聊城

出　　处：《应用化学》2009年第2期140-143,共4页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20271025);山东省教育厅科研基金(J07WC03)资助课题

摘　　要：由9-咔唑乙酸和二丁基氧化锡反应制得了新配合物{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)。通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征,用X射线单晶衍射测定了配合物的晶体和分子结构。该配合物晶体属于单斜晶系,C2/c空间群,晶胞参数a=2.797 5(13)nm,b=2.153 4(10)nm,c=1.515 4(7)nm,β=118.759(6)°,V=8.003(7)nm3,Z=4,μ=1.285 mm-1,Dc=1.386 g/cm3,F(000)=3 408,R=0.0571,wR=0.136 2,GOF=1.005。结构测定表明,它具有以Sn2O2四元环为中心,中心对称的二聚体结构。内、外环Sn原子均为五配位的畸变三角双锥构型。生物活性测试结果表明,该配合物对体外培养的乳腺癌细胞株MCF-7和结肠癌细胞株WiDr有较好的抑制活性。Organotin（Ⅳ） complex { [ （n-C4H9）2Sn（0. 5 · O2CCH2C,2H8N） （0.5 · C2H5O） ]2O}2 · （C12 H8NH） was synthesized by the reaction of n-dibutyltin oxide with （9-carbazoly）-acetic acid. The complex was characterized by elemental analysis, IR and ^1H NMR. The crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to monoclinic, with space group C2/c with a =2. 797 5（13） nm, b = 2. 153 4（10） nm, c=1.5154（7） nm,β=118.759（6）°, V=8.003（7） nm^3 Z=4,μ=1.285 mm^-1, Dc=1.386 g/cm^3, F（000） =3 408, R =0.057 1, wR =0.136 2, GOF = 1.005. The complex is a centrosymmetric structure mode with a four-member central endo-cyclic Sn2O2 unit in which two bridged oxygen atoms both connect with an exo-cyclic tin atom. The endo-cyclic tin atoms and the exo-cyclic tin atoms are all five-coordination and have a coordination geometry of a distorted trigonal bipyramid. This complex was tested in vitro against human tumour cell lines, MCF-7 and WiDr, and displayed high activity.

关 键 词：有机锡(Ⅳ)配合物 咔唑乙酸 合成 晶体结构 抗癌活性 

分 类 号：O641[理学—物理化学]