深圳市学龄前儿童流感嗜血杆菌带菌率及耐药性研究  

Haemophilus influenza-carrying rate of preschool age children in Shenzhen and results of drug resistance

作　　者：陈辉[1] 黄锐敏[1] 袁月明[1] 俞慕华[1] 段永翔[1] 

机构地区：[1]深圳市南山区疾病预防控制中心,广东深圳518054

出　　处：《中国热带医学》2009年第2期322-323,共2页China Tropical Medicine

摘　　要：目的了解深圳市健康学龄前儿童口咽部流感嗜血杆菌(Haemophilus influenza,Hi)携带率、菌型特点及对常用抗生素的耐药情况,提供Hi感染的临床防治依据。方法选择深圳市具有代表性的三所日托幼儿园健康儿童181名,进行口咽部Hi携带率监测,Hi分离株进一步作生物学分型及耐药性研究。结果从181份样品中共分离到流感嗜血杆菌45株,阳性率为24.9%。生物学分型分别为Ⅰ型2株(4.4%)、Ⅱ型13株(28.9%)、Ⅲ型18株(40.0%)、Ⅳ型2株(4.4%)、Ⅴ型2株(4.4%)、Ⅵ型2株(4.4%)、Ⅶ型0、Ⅷ型6株(13.3%)。耐药株数(耐药率)分别为:氨苄西林12株(26.7%)、复方新诺明19株(42.2%)、氯霉素8株(17.8%)、四环素10株(22.2%)、氨苄西林/舒巴坦1株(2.2%)、氨曲南1株(2.2%),头孢噻肟、头孢克肟、利福平、阿齐霉素、氧氟沙星均为0。结论深圳市学龄前健康儿童口咽部Hi生物学分型以Ⅱ型、Ⅲ型为主,对常见抗生素耐药情况不甚严重,特别对头孢噻肟、头孢克肟、利福平、阿齐霉素、氧氟沙星有较高的敏感性。Objective To understand the status of oral pharyngeal carrying rate of Haemophilus influenza in healthy preschool children in Shenzhen. Methods One hundred and eighty-one children in three representative kindergartens in Shenzhen were surveyed , and the carrying rates of Hoemophilus influenza were studied. All Hoemophilus influenza strains were biologically differentiated and their resistance to antibiotics were tested. Results 45 Haemophilus influenza strains were isolated from 181 samples with a positive rate of 24.9%. Biology Ⅰ -Ⅶ were 2 ,13, 18 ,2, 2 , 2 and 6 strains. The esistance rate to ampiciUin,trimethoprim＋sulfamethoxazole, chloramphenicol, tetracycline, ampicillin/-sulbactam, aztreonam were 26.7% ,42.2% ,17.8% ,22.2% ,2.2%, The resistance to cefotaxime, cefixime, rifampicin, azithromycin and ofloxacin were 0. Conclusion The oral pharyngeal carrying status of Haemophilus influenza was 24.9% in healthy preschool students, in Shenzhen. Haemophilus influenza is susceptible to cefotaxime,cefixime,rifampicin,azithremycin and ofloxacin.

关 键 词：流感嗜血杆菌 携带率 生物学分型 耐药性 

分 类 号：R511.7[医药卫生—内科学]