尿激酶治疗频发短暂性脑缺血发作临床研究  

Effect of Urokinase on Patients with Frequently Transient Ischemic Attack

作　　者：谢康[1] 崔煜[1] 郑重[1] 蒋宏俨[1] 许航[1] 许媛媛[1] 

机构地区：[1]安徽省蚌埠医学院第二附属医院神经内科,233040

出　　处：《中华全科医学》2009年第1期19-20,共2页Chinese Journal of General Practice

摘　　要：目的观察单次使用尿激酶对频发的颈内动脉系统短暂性脑缺血发作(transient ischemic attack,TIA)的疗效。方法62例频发颈内动脉系统TIA患者随机分为单次尿激酶治疗的尿激酶组(32例)和常规治疗的对照组(30例)。结果尿激酶组治疗后24h、3d和15d内TIA发作控制率分别为68.8%、90.7%和96.9%,均高于对照组的16.7%、56.7%和83.4%(P<0.01);尿激酶治疗后凝血功能无明显变化(P>0.05),纤维蛋白原较常规组明显降低(P<0.05)。结论早期单次使用尿激酶治疗能迅速控制频发颈内动脉系统TIA发作,有效防止脑梗死的发生。Objective To probe into the effect of urokinase taking once on patients with frequently transient isehemic attack （TIA） in the internal carotid artery system. Methods 62 patients with frequently TIA in the internal carotid artery system were randomly divided two groups：the group of Urokinase taking once （32 patients） and the group of conventional therapy （30 patients）. Results The rates of TIA paroxysm in Urokinase group were 68.8% ,90.7% and 96.9% after 24 h,3 days, 15 days. The results were lower than that in control group, 16.7% ,56.7% and 83.4% （P 〈 0.01 ） ;the blood clotting function wasn＇ t marked change（ P 〉 0.05） after using Urokinase, the fibrinogen was lower than the group of conventional therapy （P 〉 0.05 ）. Conclusion Urokinase taking once earlier could control the attacking of TIA in the internal carotid artery and prevent cerebral infarction to happen utility.

关 键 词：尿激酶 颈内动脉系统 短暂性脑缺血 单次使用 

分 类 号：R743.31[医药卫生—神经病学与精神病学]