大鼠大脑中动脉血栓栓塞脑缺血模型的实验研究  

Establishment of a Middle Carotid Arterial Embolic Stroke Model in Rats

作　　者：郑永玲[1] 胡长林[2] 

机构地区：[1]重庆市第三人民医院神经内科,重庆400014 [2]重庆医科大学附属第二医院神经内科,重庆400010

出　　处：《神经损伤与功能重建》2009年第1期25-27,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:建立病理生理过程与人类近似的脑缺血模型。方法:采用成组设计的随机对照研究,用大鼠自体血血栓注入大脑中动脉建立栓塞模型,观察缺血后6、12、24 h大鼠的神经功能评分、脑含水量和梗死灶体积。结果:模型稳定、可靠、重复性好。结论:自体血血栓栓塞模型适用于缺血性脑血管病治疗及药物评价的实验。Objective： To establish an animal model resembling human embolie stroke. Methods： Rats were subjected to a model of embolic stroke by injecting antologous blood embolus into the left internal carotid arterial. The neurologie function, brain water content, infarct volume rate were evaluated at 6,12, and 24 h after infarction. Results： The embolic stroke model mimicking human ischemia with autologous blood embolus was stable, reliable and reproducible. Conclusion： The rat embolic stroke model with autologous blood clots is useful for assessing therapeutic effects on CNS ischemic diseases.

关 键 词：自体血血栓 大脑中动脉 栓塞模型 

分 类 号：R741[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]