新型含2-取代-1,3-噻唑烷和噻唑环的亚胺类化合物的合成及生物活性  

Synthesis and Biological Activities of Novel Imine Derivatives Containing 2-Substituted-1,3-thiazolidine and Thiazole Rings

作　　者：戴红[1] 刘建兵[1] 张欣[1] 于海波[1] 秦雪[1] 秦振芳[1] 王婷婷[1] 方建新[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室天津市农药科学重点实验室,天津300071

出　　处：《有机化学》2009年第1期123-127,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20772068);国家科技支撑计划重点(No.2006BAE01A01-5)资助项目

摘　　要：通过4-[(2-氰基亚胺基-1,3-噻唑烷-3-基)甲基]-2-氨基噻唑与取代苯甲醛的缩合反应,合成了14个新型含2-取代-1,3-噻唑烷和噻唑环的亚胺类化合物5.所有化合物的结构均经1HNMR和元素分析确证,并通过X射线单晶衍射分析测定了化合物5a的晶体结构.初步生物活性试验结果表明,部分目标化合物具有一定的杀菌活性和植物生长调节活性.Fourteen new imine derivatives 5 containing 2-substituted-1,3-thiazolidine and thiazole rings were synthesized by the condensation of 2-cyanoimino-3-（2-aminothiazol-4-ylmethyl）thiazolidine with various substituted benzaldehydes. The structures of the title compounds were characterized by ^1H NMR spectra and elemental analysis. The structure of 5a was also determined by X-ray diffraction analysis. Preliminary bioassay showed that some of the target compounds exhibited fungicidal and plant growth regulatory activities to some extent.

关 键 词：2-取代-1  3-噻唑烷 噻唑 亚胺 合成 生物活性 

分 类 号：O626.2[理学—有机化学] TQ450.1[理学—化学]