人乳头状瘤病毒与食管癌的病因学关系  

Etiologic Relationship between Human Papillomavirus and Esophageal Cancer

作　　者：王修杰[1] 王旭华[1] 王朝俊[1] 陶德明[1] 肖恒怡[1] 

机构地区：[1]华西医科大学肿瘤研究所

出　　处：《中国肿瘤临床》1998年第4期270-273,共4页Chinese Journal of Clinical Oncology

基　　金：纽约中华医学基金;四川省卫生厅科研基金

摘　　要：为探索人乳头状瘤病毒（ＨＰＶ）感染与四川盐亭地区食管癌高发的病因学关系，用生物素标记的ＨＰＶ１６ＤＮＡ探针对盐亭食管癌高发区食管癌、正常食管上皮及成都食管癌低发区正常食管上皮脱落细胞进行原位杂交，检测ＨＰＶ１６ＤＮＡ。结果：盐亭地区食管癌及正常食管上皮ＨＰＶ１６ＤＮＡ阳性率分别为５０．５％（２０／４０）和６２．１％（３６／５８），两者无显著性差异（Ｐ＞０．０５）；成都地区正常食管上皮ＨＰＶ１６ＤＮＡ阳性率为１５．４％（６／３９），低于盐亭地区正常食管上皮的阳性率，有显著性差异（Ｐ＜０．０１）。研究结果表明，ＨＰＶ感染与四川盐亭地区食管癌高发有关。Objective: To study the etiologic relationship between human papillomavirus (HPV) infection and formation of esophageal cancer (EC) in Yanting area of Sichuan province (high incidence region). Method: Exfoliated cells of EC from patients in Yanting and normal esophageal epithelia (NEE)from persons in low incidence area (Chengdu) were studied by hybridization in situ with HPV16　DNA probe for the presence of HPV16 DNA. Results showed that the HPV16 DNA　positive rates of EC and NEE from Yanting were 50.0% (20/40) and 62.1% (36/58)respectively.No significant difference was found　statistically(P>0.05).The　HPV16　DNA　positive rate of NEE from Chengdu was 15.5% (6/39) which was much lower than that in Yanting (P<0.01). It is suggested that HPV infection is closely related with the high incidence of EC in Yanting area of Sichuan province. 

关 键 词：人乳头状瘤病毒 食管癌 原位杂交 病因学 

分 类 号：R735.102[医药卫生—肿瘤]