食管小细胞癌的临床分析  

A clincal study in undifferertiated small cell carcinoma of the esophagus

作　　者：陈剑[1] 张鼎儒[1] 李鸿波[1] 郭宇飞[1] 王健刚[1] 

机构地区：[1]河南省焦作市第二人民医院,454100

出　　处：《中国临床实用医学》2009年第1期35-36,共2页China Clinical Practical Medicine

摘　　要：目的探讨食管小细胞癌患者的临床特点、治疗及预后。方法对43例食管小细胞癌患者进行了回顾性分析。男27例，女16例，食管胸上段2例，胸中段11例，胸下段30例。病变范围2．5～12．5cm，病变长度平均值6．2cm，单纯手术4例，单纯放射治疗7例，单纯化疗2例，手术＋化疗18例，手术＋放射治疗2例，放射治疗＋化疗9例，手术＋放射治疗＋化疗1例。结果单纯手术者、单纯放射治疗者、单纯化疗者中位生存时间分别为11、5、4个月，而手术＋化疗、放射治疗＋化疗和手术＋放射治疗＋化疗者中位生存期分别为13、11、15个月，全组中位生存期为11．5个月，生存最长者已达63个月和72个月。1、3、5年生存率分别为53．48％、16．28％、11．63％。结论对于食管小细胞癌，有计划的综合治疗，尤其是早期食管小细胞癌的手术与化疗对患者的治疗更有意义，可以提高远期疗效，延长患者的生存期。Objective To investigate the clinical characteristics, treatment and prognosis of undifferentiated small cell esophageal carcinomal （SCEC）. Methods 43 patients with SCEC were treated. There are 27 male and 16 female. The primary tumor was located in the upper thoracic in 2 patients, Mid thoracic in 11, and lower in 30. Thirteen patients were treated with surgery alone, radiotherapy alone, or chemotherapy alone, the remaining 30 patients were treated with combined modality. Results The median of survivals was 11.5 months for all patients, with 11 months for surgery,5 months for radiotherapy,4 months for chemotherapy, 13 months for surgery combined with chemotherapy, 11 months for chemoradiotherapy and 15 months for surgery combined with chemoradiotherapy,respectively. The survival rates at 1,3, and 5 years were 53.48%, 16.28%, 11.63%, respectively. Conclusion We recommend that combined modality should be used for SCEC. The combination of surgery and multidrug chemotherapy may improve the treatment outcomes for the patients with early stage SCEC.

关 键 词：食管肿瘤/外科学 食管肿瘤/药物疗法 食管肿瘤/放射疗法 综合治疗 

分 类 号：R735.1[医药卫生—肿瘤] R739.41[医药卫生—临床医学]