小柴胡片联合干扰素治疗慢性乙型肝炎肝纤维化的临床研究  

Clinical study of Xiaochaihu in combination with in terferon in the treatment of Chronic Hepatitis B Fibrosis

作　　者：何炳福[1] 周建康[2] 沈华江[2] 

机构地区：[1]绍兴市疾病预防控制中心传染病防制科,浙江绍兴312071 [2]绍兴市第六人民医院肝科,浙江绍兴312000

出　　处：《中国中西医结合消化杂志》2008年第6期384-385,387,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]观察小柴胡片联合干扰素(IFN)治疗慢性乙型肝炎(CHB)肝纤维化的临床疗效。[方法]选择CHB患者137例,随机分为2组,对照组(64例)用IFN300万U隔日1次肌内注射,治疗组(73例)加用小柴胡片,疗程均为6个月,观察2组治疗前、后肝纤维化及影像学指标的变化。[结果]2组疗程结束后肝功能和肝纤维化指标均有明显改善,治疗组优于对照组,且能改善影像学指标(P<0.05,<0.01)。[结论]小柴胡片与IFN联合应用对CHB具有较好的临床疗效,在改善肝纤维化方面两药合用具有协同作用。[Objective]To observe the clinical effect of Xiaochaihu in combination with interferon in the treatment of chronic hepatitis B fibrosis. [Methods]One huadred and thirty seven patients with the chronic hepatitis B were chosen and randomly divided into two groups. Sixty four patients in the control group were treated with interferon 3MU intramuscular injections, while 73 patients in the treatment group being treated with interferon in combination with Xiaochaihu. The change of liver fibrosis and imageological indexes before and after 6 months of the treatment in two groups were investigated. [Results]The liver fibrosis indexes improved in both groups. But the effect in the treatment group was better than the control group, and imageological index in the treatment group was improved as well. [Conclusion ]Xiaochaihu in combination with interferon had synergistic effect in the treatment of chronic hepatitis B fibrosis.

关 键 词：乙型肝炎 慢性 小柴胡片 干扰素 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统] R289.5[医药卫生—内科学]