核因子-κBp65与IκBα在口腔白斑及鳞癌中的表达  

Expressions of NF-κBp65 and IκBα in oral leukoplakia and oral squamous cell carcinoma

作　　者：高黎[1] 张彦喜[1] 石爱梅[2] 

机构地区：[1]郑州大学第四附属医院口腔科,450052 [2]郑州大学第一附属医院口腔科

出　　处：《实用口腔医学杂志》2009年第1期58-61,共4页Journal of Practical Stomatology

摘　　要：目的:探讨核因子-κB(nuclear factorκB,NF-κB)p65及其抑制蛋白IκBα在口腔白斑(OLK)及口腔鳞癌(OSCC)中的表达及其关系。方法:应用免疫组织化学技术检测正常口腔黏膜上皮(n=10)、OLK(n=46)及OSCC(n=36)中的NF-κBp65、IκBα表达。结果:NF-κBp65在正常口腔黏膜、单纯增生型OLK、异常增生型OLK及OSCC的表达率分别为:0%、9.09%、42.86%、72.22%,4组之间差异具有统计学意义(P<0.05);IκBα在4组中呈动态表达,分别为:10%、81.82%、48.57%、86.11%,4组之间差异具有统计学意义(P<0.05)。NF-κBp65与IκBα的表达在OLK癌变过程中呈负相关(P<0.05),在癌组织中呈正相关(P<0.05)。结论:二者可能是检测OLK的恶变潜能及OSCC早期诊断的敏感指标。Objective：To investigate the expressions of NF-KBp65 and IκBα in oral leukoplakia（OLK） and oral squamous cell carcinoma（OSCC） as well as their correlationship. Methods： hnmunohistochemical staining technique was used to determine the expressions of NF- KBp65 and IκBα in all specimens ： 46 OLK specimens and 36 OSCC specimens; 10 eases of normal oral mueosa（NM） tissues were regarded as normal control. Results：The pos- itive rates of NF-KBp65 in NM, simple hyperplasia OLK, dysplasia OLK and OSCC were 0% , 9. 09% , 42.86% , and 72.22% respectively, and a statistical significance was observed among them（ P 〈 0. 05 ）. There were expressions of IκBα in each stage with different levels which showed a dynamic process： The positive rates were 10.00% , 81.82% , 48.57% , and 86.11% respectively, and a statistical significance was observed among them（P 〈 0.05）. Spearman rank correlation analysis showed a correlation between expressions of NF-KBp65 and IκBα protein in OLK（P 〈0.05） and in OSCC specimens （P 〈0.05）. Conelusion：NF- KBp65 and IκBα protein may be useful for evaluating the malignant potential of OLK and early diagnosis of OSCC.

关 键 词：口腔白斑 口腔鳞状细胞癌 核因子-ΚB IΚBΑ 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]