人工泪液对成年近视眼角膜厚度的影响  

Effects of artificial tears on corneal thickness in adult myopia

作　　者：张凤兰[1] 高磊[1] 王富华[1] 代秀玉[1] 谭丽霞[1] Alvin K H Kwok 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院眼科,中国山东省烟台市264000 [2]香港养和医院眼科

出　　处：《国际眼科杂志》2009年第1期8-10,共3页International Eye Science

摘　　要：目的:研究人工泪液爱丽和倍然对成年近视眼角膜厚度的影响。方法:应用Orbscan Ⅱ角膜地形图系统(Orbscan,Inc,SaltLakeCity,UT,USA,Version3.00E)对滴人工泪液爱丽或倍然0.5h后的最薄角膜厚度(THN)变化进行测量,38例(76眼)被随机分成爱丽组和倍然组,分别于滴药前和滴药后0.5h进行3次THN测量。结果:两组THN在滴药前无差异(t=0.264),但滴药0.5h后两组THN均显著增加(爱丽组5.57±7.00μm,t=4.906,P<0.01,倍然组7.89±7.64μm,t=6.369,P<0.01),两组之间的角膜厚度变化无显著性差异(t=1.381,P>0.05);爱丽组共有32眼(84%)角膜厚度增加,而倍然组33眼(87%)角膜厚度增加。结论:对生产工艺要求相对严格的人工泪液能短时间内显著增加近视眼角膜厚度,角膜厚度的变化可作为评估人工泪液等眼药制剂舒适度的客观指标之一。AIM ： To study the effects of Sodium Hyaluronate （HA） and Bion Tears on corneal thickness in adult myopic patients. METHODS： A total of 38 cases （76 eyes） were involved in this study. Three consecutive corneal measurements （the thinnest point of the cornea, THN） were evaluated before and half an hour after the instillation of one drop of HA in one eye and Bion Tears in the other at random with the Orbscan Corneal Topography System II （Orbscan, Inc, Salt Lake City, UT, USA, Version 3.00E）. RESULTS： There were no significant between-group differences in baseline variable （t=0. 264）. Thirty minutes after the instillation of HA and Bion tears, THN were significantly increased by 5.57 ± 7.00μ m （ t = 4.906, P 〈 0.01 ） and 7. 89 ±7.64μm （t=6.369, P〈0.01） respectively. However, there were no between-group differences in THN changes（t = 1. 381,P〉 0.05）. Increase in the corneal thickness were found in 32 eyes （84%） and 33 eyes （87%） for the HA and Bion tears group, respectively. CONCLUSION： Artificial tears including HA and Bion Tears can significantly increase the corneal thickness in a short period of time. Corneal thickness can be used as one of the objective indices for evaluating the quality and therapeutic role of artificial tears.

关 键 词：人工泪液 角膜厚度 OrbscanⅡ角膜地形图系统 

分 类 号：R778.11[医药卫生—眼科]