丝裂霉素C与近视眼受术者LASEK术后并发症的相关性  

Study on the association of mitomycin-C with complications after LASEK for myopia

作　　者：燕振国[1] 王敏[1,2] 徐朝晖[1] 张丽[1] 

机构地区：[1]兰州军区兰州总医院眼科中心,中国甘肃省兰州市730050 [2]兰州大学临床医学系,中国甘肃省兰州市730000

出　　处：《国际眼科杂志》2009年第1期113-115,共3页International Eye Science

摘　　要：目的:探讨准分子激光上皮下角膜磨镶术(laser-assisted subepithelial keratomileusis,LASEK)治疗近视中应用0.2g/L丝裂霉素C(0.2g/L mitomycin C,MMC)与术后并发症,尤其与角膜上皮下雾状混浊(Haze)的相关性。方法:将我院2a期间接受LASEK术的受术者资料193例根据术式不同分为常规组92例(184眼)和MMC组101例(199眼)。采用统计学方法统计术后两组Haze发生率及其它并发症发生率,并对相关数据进行比较分析。术后随访期均为12mo。结果:两组均无Ⅱ级以上Haze的发生。两组屈光度为-6.00^-8.00DS时Ⅱ级Haze,≥-8.00DS时Ⅰ级Haze及Ⅱ级Haze的发生率比较,差异均有统计学意义(P<0.05)。其他并发症比较无统计学差异。结论:0.2g/L MMC可减少LASEK术后Haze的形成,尤其对高度近视受术者作用更加明显,并且无明显上皮毒性。AIM： To investigate the association of using 0. 2g/L mitomycin-C （MMC） during laser-assisted subepithelial keratomil-eusis （LASEK） with postoperative complications, especially haze. METHODS： According to the different way of operating, 193 patients performed LASEK during 2 years were divided into routine group （92 patients 184 eyes） and MMC group （101 patients 199 eyes）. Incidence rates of haze and other complications in two groups were calculated, and correlated variables were compared by method of statistical analysis. The follow-up period of all patients was 12 months. RESULTS： Higher than grade Ⅱ haze weren＇t found in two groups. Differences of incidence rates of grade Ⅱ haze with diopter -6.00 - -8.00DS and grade Ⅰ haze and grade Ⅱ haze with diopter ≥-8.00DS were all considered as statistically significant （ P 〈 0, 05）. The comparison of other complications was all no significantly difference between two groups. CONCLUSION ： It is obviously effective that 0.2g/L MMC reduces the formation of haze, especially for high myopia patients, with no apparent epithelium toxic effect.

关 键 词：丝裂霉素C 准分子激光上皮下角膜磨镶术 角膜上皮下雾状混浊 

分 类 号：R779.63[医药卫生—眼科]