表皮生长因子及受体与增生性玻璃体视网膜病变  

EGF/EGFR and proliferative vitreoretinopathy

作　　者：张磊[1] 孙晓东[1] 

机构地区：[1]上海交通大学附属第一人民医院眼科,中国上海市200080

出　　处：《国际眼科杂志》2009年第1期132-134,共3页International Eye Science

基　　金：中国上海市科委浦江人才发展计划基金资助项目[No.PJ(2008)00594]~~

摘　　要：表皮生长因子(epidermal growth factor,EGF)与其受体(ep-idermal growth factor receptor,EGFR)结合后可通过特定的信号传导通路调节细胞的增生、迁移、粘附等活动。研究发现EGF/EGFR可诱导视网膜色素上皮(retinal pigmentepithelial,RPE)细胞增生、移行,从而促进增生性玻璃体视网膜病变(proliferative vitreoretinopathy,PVR)的发生发展。我们通过本文从EGF/EGFR的结构、功能、参与PVR形成的机制等方面进行综述,并展望拮抗EGF/EGFR信号传导通路的方法在治疗PVR上的应用前景。Epidermal growth factor （EGF） combining with epidermal growth factor receptor （EGFR） plays an important role in inducing cell proliferation, migration, adhesion and so forth by specific signal transduction. Recently, EGF/EGFR was found to stimulate retinal pigment epithelial （RPE ） cells to proliferate and migrate which induce the formation and development of proliferative vitreoretinopathy （PVR）. We focused on the structure, function of EGF/EGFR as well as the mechanism of EGF/ EGFR acting in PVR and also discussed the prospect of using inhibitor of EGF/EGFR signaling pathway as a mean to improve PVR.

关 键 词：表皮生长因子及受体 增生性玻璃体视网膜病变 增生 迁移 

分 类 号：R774.1[医药卫生—眼科] R735.2[医药卫生—临床医学]