奥卡西平治疗儿童癫的疗效及药物不良反应  

Curative Effect and Adverse Reaction of Oxcarbazepine on Treating Epilepsy in Children

作　　者：陈倩[1] 李尔珍[1] 罗桂芳[1] 许克铭[1] 

机构地区：[1]首都儿科研究所附属儿童医院神经科,北京100020

出　　处：《实用儿科临床杂志》2009年第1期53-55,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨奥卡西平治疗儿童癫的疗效,并观察其药物不良反应。方法对129例各种类型癫患儿采用逐步加量法予口服奥卡西平,依据服药前发作频率分为2组。A组:服药前3个月内有3次以上发作的患儿在服用奥卡西平5个月后进行疗效的初始判断;B组:服药前1a发作3次以上者,服药1a后进行初始疗效判断。并观察药物不良反应及药物保留率。结果1.疗效判断:129例中能参加初始疗效判断的局限性发作癫患儿共60例。其中A组47例服药5个月后,发作完全控制者22例(45.8%),显效7例(14.6%),有效3例(6.3%),有效者共32例,有效率为66.7%;无效15例,无效率为33.3%。B组13例服药1a后,发作完全控制者12例(92.3%),无效1例(7.7%)。2组总计有效率为73.3%,无发作率为56.7%;单用奥卡西平治疗者,有效率为75.6%,无发作率为62.2%;联合用药者,有效率为66.7%,无发作率为40%。2.不良反应:31例(24%)患儿发现不良反应,但多数为一过性,症状轻微。3.药物保留率:1a药物保留率为72.2%,2a药物保留率为80%。结论奥卡西平具有满意的抗癫疗效,不良反应较轻微,药物保留率高,患者有较好的依从性和耐受性。Objective To study the curative effect and adverse reaction of Oxcarbazepine （ OXC ） on treating epilepsy in children. Methods One hundred and twenty - nine children with different types of epilepsy were orally given OXC,and the drug dose was added gradually. According to the seizure frequency,the cases were divided into 2 groups. Group A：more than 3 seizures occurred in 3 months prior to to take OXC;group B：more than 3 seizures occurred in 1 year prior to taking OXC. After 5 months and 1 year from beginning to take OXC,the original curative effect of the 2 groups was evaluated, respectively;on the other hand, the adverse reaction and the retention were studied. Resuits 1. Original effect ： the rate of seizure - free was 45.8 % and the total curative efficiency was 66.7% in group A （ n = 47 ） ; the rate of sei- zure - free was 92.3% in group B（n = 13） ;in 60 partial epilepsy children,the rate of seizure - free was 56.7% and the total curative effi- ciency was 73.3% ; Both rates were 62.2% and 75.6% of patients with OXC monotherapy and 40% ,66.7% of patients were given OXC in combination with another antiepileptic drugs. 2. Drug adverse reaction ：24% of patients were found to have adverse reaction and most of the symptoms were light and most transient. 3. Tolerability：patients＇ retention of OXC in 1 year was 72.2% ,and in 2 years was 80.0%. Conclusions The antiepileptic effect of OXC is satisfactory and adverse reaction is light and mostly transient, OXC as a new antiepileptic drug is well tolerated as monotherapy and adjunctive therapy and should be used extensively.

关 键 词：奥卡西平 疗效 不良反应 药物保留率 癫痫 儿童 

分 类 号：R742.1[医药卫生—神经病学与精神病学]