PAI-1和超敏CRP与代谢综合征合并冠心病关系的研究  

Study on the Relationship of Plasminogen Activator Inhibitor type 1 and Ultrasensitive C-reative Protein in Patient with Metabolic Syndrome and Coronary Heart Disease.

作　　者：闫文珍[1] 黄淑田[1] 王瑞英[1] 杨利国[1] 仝珊[1] 

机构地区：[1]山西医科大学第二医院心内科,太原030001

出　　处：《医学研究杂志》2009年第2期43-45,共3页Journal of Medical Research

基　　金：山西省高校科技开发项目(200713066)

摘　　要：目的探讨PAI-1和超敏CRP与代谢综合征(MS)合并冠心病(CHD)之间的关系。方法将87例MS患者分为MS合并CHD组和单纯MS组,选择同期正常健康人30例(年龄、性别与代谢综合征两组匹配)作为正常对照组;比较其体重指数(BMI)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、纤溶酶原激活物抑制剂1(PAI-1)、超敏C反应蛋白(CRP)的变化。结果MS组BMI、WC、FPG、DBP、TG均高于对照组(P<0.05),HDL-C低于对照组(P<0.05)。且合并CHD组SBP、DBP均高于单纯MS组(P<0.05),HDL-C低于单纯MS组(P<0.05)。WC、TG显著高于单纯MS组(P<0.01)。MS组血PAI-1、hsCRP含量显著高于对照组(P<0.01),且MS合并CHD者血浆PAI-1、hsCRP含量显著高于单纯MS组(P<0.01)。PAI-1与WC、SBP、DBP、TG、hsCRP呈正相关(r值分别为0.51,0.42,0.33,0.42和0.50,P<0.05),与HDL-C呈负相关(r=-0.47,P<0.05)。结论表明PAI-1和hsCRP与代谢综合征、冠心病之间存在密切的相关性,在代谢综合征、冠心病的发生发展中发挥重要作用;测定血浆PAI-1、hsCRP有可能作为代谢综合征冠心病的预测因子。Objective To investigate the relationship of plasminogen activator inhibitor type 1 （PAl - 1 ） and ultrasensitive C - reative protein （hsCRP） in patient with metabolic syndrome and coronary heart disease. Methods Between June 2006 and December 2007, 87 patients with metabolic syndrome were divded into two groups：simple MS group which consisted of 45 patients and MS with CHD group which consisted of 42 patients. 30 health people at the same stage, whose age and sex were similar with those in MS group served as normal control group. The levels of body mass index （BMI） , waist circumference（WC） , systolic blood presser（SBP） , diastolic blood presser（ DBP）, trigIyceride （ TG）, total cholesterol （ TC ）, high density lipoprotein cholesterol （ HDL - C ）, fasting plasma glucose （ FPG ）, PAI - 1 and hsCRP were measared. Results BMI,WC, FPG,SBP, DBP,TG,PAI - 1 and hsCRP in both MS groups were higher than those in normal control group （ P 〈 0.05 ）. HDL - C was lower than that in normal control group （ P 〈 0. 05 ）. Plasma PAI- 1 level was positively correlated with WC, SBP, DBP, TG, hsCRP（P 〈 0. 05）. Conclusion There was close relation of PAI- 1 and hsCRP to MS and CHD. Plasma PAI- 1 and hsCRP played an important part in the occurrence and development of MS and CHD. Plasma PAI- 1 and hsCRP were involved in the occurrence and development of MS with CHD. Measurement of PAI- 1 and hsCRP could be used as a predictive factor for MS with CHD.

关 键 词：代谢综合征 纤溶酶原激活物抑制剂1 超敏C反应蛋白 冠心病 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R589[医药卫生—临床医学]