胃印戒细胞癌和癌旁球样型增生细胞DNA含量的研究  

Study on the cellular nuclear DNA content in the gastric signetring cell carcinoma and globoid dysplasia cell

作　　者：潘彦珞[1,2,3] 王新允[1,2,3] 赵天茹[1,2,3] 张菊芳[1,2,3] 张金时[1,2,3] 郑海燕[1,2,3] 张乃鑫[1,2,3] 

机构地区：[1]天津医科大学病理学教研室 [2]天津医科大学计算机中心 [3]天津医科大学第二医院病理科

出　　处：《临床与实验病理学杂志》1998年第2期146-148,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的：了解球样异型增生细胞的癌前意义。方法：应用ＣＭＩＡＳ－００７型图象分析系统检测３４例胃印戒细胞癌、４４例球样异型增生细胞和１５例正常胃粘膜上皮细胞的ＤＮＡ含量。结果：胃印戒细胞癌、球样异型增生细胞和正常胃粘膜之间ＤＮＡ含量差异有显著性（Ｐ＜０．０５及Ｐ＜０．０１）。直方图上，正常胃粘膜细胞呈位于２Ｃ区的单峰型。胃印戒细胞癌的众数峰右移，分布分散，各例都有＞５Ｃ的非整倍体细胞出现。球样异型增生细胞的图象介于两者之间，其中Ⅲ级球样异型增生细胞含有＞５Ｃ的非整倍体细胞。结论：球样异型增生细胞是一种异常增生细胞，是胃印戒细胞癌的癌前病变。Purpose To understand precancerous significance of globoid dysplasia cells. Methods Cellular nuclear DNA content was measured by CMIAS007 image analysis system in 34 cases of gastric signetring cell carcinoma (SCC) and 44 cases globoid dysplasia cells (GDC) in the pareneoplastic tissue, as well as in 15 cases of normal gastric specimens. Results The mean DNA value increased significantly from normal gastric mucus membrane, GDC to SCC (P<005). In histograms, normal gastric tissue showed a singlepeak type located at 2C. SCC showed lower multipeaks which migrated to 4C and spread widely with more aneuploid (>5C) cells. The histograms of GDC was between normal tissue and SCC, and there were also some aneuploid cells in Ⅲ grade GDC. Conclusions These results suggest that GDC may be an abnormal proliferating cell and a precancerous lesion of SCC. 

关 键 词：胃肿瘤 印戒细胞癌 球样异型增生 DNA 

分 类 号：R735.202[医药卫生—肿瘤]