胃癌组织中微血管密度及其临床意义  

Clinical Significance of Microvessel Density in Gastric Carcinoma

作　　者：王鸿程[1] 陈立武[1] 黄泽文[1] 杜建[2] 

机构地区：[1]福建中医学院附属第二人民医院,福建福州350003 [2]福建中医学院中西医结合研究院,福建福州350108

出　　处：《福建中医学院学报》2009年第1期6-8,共3页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省科技厅重点项目(2005Y028)

摘　　要：目的探讨胃癌组织中的微血管密度(microvessel density,MVD)及其临床意义。方法采用免疫组化S-P法,检测80例经手术切除的胃癌组织中CD34标记的肿瘤MVD,分析其与临床病理因素及预后的关系。结果CD34表达于大部分毛细微血管,CD34标记的微血管密度最高区域多为肿瘤细胞浸润的前缘部位;胃癌中MVD显著高于胃癌旁组织和正常胃组织(P<0.01);胃癌MVD与TNM分期、肿瘤浸润深度、淋巴结转移显著相关(P<0.01);胃癌高MVD组5a生存率为21.9%,显著低于低MVD组(42.9%);Kaplan-Meier生存率分析,Logrank为6.24(P<0.05)。结论肿瘤MVD可作为评估胃癌术后复发转移和预后的重要指标。Objective To explore the clinical significance of microvessel density （MVD） in gastric carcinoma. Methods Immunohistochemistral S-P method was used to detect the tumor MVD marked by CD34 in 80 cases of gastric carcinoma, and the correlations between MVD and clinicopathologic feature, prognosis were analyzed. Results Nearly all microvessel expressed CD34 in gastric carcinoma, the highest region of tumor microvascular density marked by CD34 was the anterior margin of the tumor cell invasion. The MVD in gas- tric carcinoma was significantly higher than that in adjacent tissues and normal gastric tissues （P〈0.01）, which was significantly correlated with TNM stage, invasive depth and lymph node metastasis （P〈0.01）. In the cases of gastric carcinoma, the 5 year survival rate in the high MVD group （21.9%） was significantly lower than that in the low MVD group （42.9%） from the Kaplan-Meier survival analysis （Logrank=6.24, P〈O.05）. Conclusion Tumor MVD is an important index to evaluate recurrent or metastasis and prognosis of gastric carcinoma.

关 键 词：胃癌 微血管密度 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]