外围型非小细胞肺癌CT表现与DNA含量的关系  

A Correlative Study of CT Manifestations and DNA Contents in Peripheral NSCLC

作　　者：周智洋[1,2,3,4] 邱运荣[1,2,3,4] 庄文华 方功德[1,2,3,4] 尹敬璧 何伟华[1,2,3,4] 

机构地区：[1]广东省珠海市医疗中心医学影像中心 [2]江西医学院第二附属医院放射科 [3]江西医学院病理解剖教研室 [4]江西医学院第一附属医院放射科

出　　处：《实用放射学杂志》1998年第6期323-326,共4页Journal of Practical Radiology

摘　　要：目的：通过外围型非小细胞肺癌（ＮＳＣＬＣ）的ＣＴ表现与ＤＮＡ含量之间的关系的分析，提高ＣＴ对肺癌生物学行为认识水平。方法：通过ＣＴ和ＦＣＭ对照的方法，回顾分析４６例ＮＳＣＬＣ的ＣＴ表现与ＤＮＡ含量之间的内在联系。结果：ＮＳＣＬＣ的ＤＩ值明显高于正常肺组织（Ｐ＜０．０５），异倍体率８３％，二倍体率１７％，而正常肺组织皆为二倍体。ＮＳＣＬＣ瘤体直径大于３ｃｍ的ＤＩ值高于小于３ｃｍ的，并且异倍体也高。瘤体轮廓呈毛刺边缘的ＤＩ值高于分叶和光滑状边缘。但它们之间的ＤＮＡ倍体类型没有出现差异，也没有发现ＤＮＡ指数（ＤＩ）与胸膜改变有关，但是ＮＳＣＬＣ出现淋巴结转移者ＤＩ值较高。结论：ＦＣＭ检测ＤＮＡ含量可作为评价肿瘤生物学行为有益的补充方法。作者认为，由于ＤＮＡ含量与预后相关，因此可以从外围型ＮＳＣＬＣ的ＣＴ表现来推测其预后。Objective:By analysis of relationship between CT manifestations to DNA contents in peripheral non-small cell lung carcinoma (NSCLC),to improve CT knowledges of biologic behavior of lung carcinoma.Methods:A correlative study of CT and FCM on 46 cases with peripheral non-small cell lung carcinoma(NSCLC)was made.The DNA contents of tumour and normal lung tissue were determined by means of flow cytometry(FCM).Results:DMA index(DI)of NSCLC was significantly higher than that of normal lung (p<0.005),aneuploidy was found in 83% and diploidy in 17% in NSCLC, whereas only diploidy was found in normal lung.Tumours which were over 3 cm in diameter had higher DI than those under 3 cm,and with percentage of aneuploidy higher as well.And tumours with spiculated margin had higher DNA contents than those with lobulated or smooth margins,but no significant difference in the type DNA ploidy between them was observed.DI value was not correlated with pleural changes,but it was higher in NSCLC with lymph node metastasis.Conclusion:It is proposed that the analysis of DNA contents by FCM provides a beneficial complement for the evaluation of tumours behavior and a useful aid in planning treatment.Because of DNA contents are correlated with prognosis of patients with peripheral NSCLC,so that it is available to predict prognosis by CT findings of tumors.

关 键 词：肺肿瘤 非小细胞肺癌 诊断 CT DNA 

分 类 号：R734.2[医药卫生—肿瘤]