尼莫地平治疗蛛网膜下腔出血120例疗效观察  

Effect of Nimodipine for 120 patients with subarachnoid hemorrhage

作　　者：吴冰[1] 甄勇[1] 刘兵[1] 杨忠熙[1] 罗祺[1] 

机构地区：[1]吉林大学第一医院神经外科,吉林长春130021

出　　处：《吉林医学》2009年第1期20-21,共2页Jilin Medical Journal

摘　　要：目的:探讨尼莫地平治疗蛛网膜下腔出血的疗效。方法:将120例SAH患者随机分为两组,各60例,治疗组采用尼莫地平持续泵入加口服药物治疗,并与对照组常规治疗进行对比观察。结果:两组治愈率比较,治疗组明显高于对照组,差异有统计学意义(P<0.01);治疗组脑血管痉挛(CVS)发生率低于对照组,差异有统计学意义(P<0.01);再出血发生率两组比较差异无统计学意义(P>0.05);死亡率两组比较差异无统计学意义(P>0.05)。结论:尼莫地平明显降低SAH后CVS发生率,提高CVS治愈率且无增加再出血的风险,但不能降低SAH后的死亡率。Objective To explore the effect of Nimodipine in the treatment of subarachnoid hemorrhage （SAH）. Method Total 120 cases with SAH were randomly divided into two groups, 60 cases in each group. The treatment group was given continuous pumped - in Nimodipine plus oral medication, the control group with conventional therapy, and the effects was compared between the two groups. Results The eure rate in the treatment group was significantly higher than the control group, and the difference was significant （ P 〈 0.01 ）. The cerebral vasospasm （CVS） rate in the treatment group was lower than the control group, and showed significant difference （P 〈 0.01 ）. The incidence of rehaemorrhagia and mortality between the two groups showed no significant difference （ P 〉 0.05 ）. Conclusion Nimodipine can significantly reduce the incidence of CVS after SAH and doesnt increase the risk of rehaemorrhagia, but can not reduce the mortality after SAH.

关 键 词：蛛网膜下腔出血 尼莫地平 脑血管痉挛 

分 类 号：R743.3[医药卫生—神经病学与精神病学]