肺硬化性血管瘤的诊断及研究现状  

Diagnostic and study status of sclerosing hemangioma of the lung

作　　者：薛娣[1] 魏中华[1] 邵睿[1] 

机构地区：[1]江苏大学附属人民医院病理科,江苏镇江212000

出　　处：《吉林医学》2009年第1期24-25,共2页Jilin Medical Journal

摘　　要：目的:探讨肺硬化性血管瘤(SHL)的组成成分及组织起源,提高对其临床病理特征的认识。方法:综合分析15例SHL临床特点,免疫组化及病理形态学特征。结果:SHL主要由圆形细胞和表面立方细胞两种细胞类型组成,组织结构多样,主要表现为实性区,乳头区,出血区和硬化区四种结构,大部分实性区圆形瘤细胞对上皮抗原(EMA),甲状腺转录因子(TTF-1)及波形蛋白(vimentin)阳性,也有部分圆形瘤细胞对神经元特异性希醇化酶(NSE)、突触素(SYN)、雌激素受体(ER)和孕激素受体(PR)呈阳性反应,EMA、TTF-1和表面活性蛋白(SP-B)对乳头表面立方细胞呈阳性反应。结论:实性的圆形细胞和乳头表面立方细胞均为SHL的肿瘤细胞,可能起源于原始的未分化的呼吸道上皮。Objective To investigate the composition and histogenesis of sclerosing hemangioma of the lung （SHL） , in order to elevate the recognition of elinicopathological feathers of SHL. Method The clinicopathlogical and immunohistochemical feathers were reviewed in 15 cases of SHL. Results SHL has a characteristic architecture composed of round cell and surface cubic cell. It has a variety of tissnlar structure, mainly expression with four regions that contains solid regions, papillary regions, angiomatoid regions and sclerosing regions. The expression of round cells about EMA, TTF - 1, vimentin is positive and the expression of round cells about NSE, SYN, ER, PR is positive partly. As far as EMA, TTF - 1 and SP - B are concered, the expression of surface cubic cell is positive. Conclusion Both solid round cells and surface cubic cells are neoplastic. SHL is a tumor that probably originates from the epithelial cell of primary respiratory tract.

关 键 词：肺硬化性血管瘤 病理特征 免疫组化 鉴别诊断 

分 类 号：R734.2[医药卫生—肿瘤] R735.2[医药卫生—临床医学]