Isolation and NMR Study on Swainsonine from Locoweed,Astragalus strictus  

作　　者：ZHAO Bao-yu LIU Zhong-yan WANG Jian-jun SUN Li-sha WANG Zhan-xin WANG Yin-chao 

机构地区：[1]College of Veterinary Medicine, Northwest A ＆ F University, Yangling 712100, P.R.China [2]Xi＇an Municipal Public Security Bureau, Xi＇an 710000, P.R.China [3]Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R.China

出　　处：《Agricultural Sciences in China》2009年第1期115-120,共6页中国农业科学（英文版）

基　　金：the National Natural Science Foundation of China (39770571)

摘　　要：Locoweed is a poisonous plant wildly distributed in most area of the world and can cause livestock poisoning or death with significant economic loss. The principal responsible for its toxicity is indolizidine alkaloid swainsonine, a new potential anticancer and antiviral drug. Astragalus strictus is mainly distributed in Tibet of China and is a serious hazard to the local livestock industry. To analyze its main toxic ingredients and supply more structural information and more accurate data, swainsonine has been isolated from this plant by D101 macroporous resin and the ^1H and ^13C chemical shifts of the compound has been assigned by 1D-NMR and 2D-NMR techniques. At the same time, complete assignments of swainsonine＇s ^13C spectral signals are reported.Locoweed is a poisonous plant wildly distributed in most area of the world and can cause livestock poisoning or death with significant economic loss. The principal responsible for its toxicity is indolizidine alkaloid swainsonine, a new potential anticancer and antiviral drug. Astragalus strictus is mainly distributed in Tibet of China and is a serious hazard to the local livestock industry. To analyze its main toxic ingredients and supply more structural information and more accurate data, swainsonine has been isolated from this plant by D101 macroporous resin and the ^1H and ^13C chemical shifts of the compound has been assigned by 1D-NMR and 2D-NMR techniques. At the same time, complete assignments of swainsonine＇s ^13C spectral signals are reported.

关 键 词：chemical shift assignment LOCOWEED NMR SWAINSONINE 

分 类 号：S68[农业科学—观赏园艺]