SWAINSONINE

作品数:16被引量:68H指数:5
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相关领域:农业科学更多>>
相关作者:陶厚权王学红梁剑平郝宝成胡永浩更多>>
相关机构:复旦大学上海交通大学医学院附属瑞金医院厦门大学中国农业科学院兰州畜牧与兽药研究所更多>>
相关期刊:《Advances in Reproductive Sciences》《色谱》《Animal Husbandry and Feed Science》《湖北农业科学》更多>>
相关基金:国家自然科学基金国家高技术研究发展计划中央级公益性科研院所基本科研业务费专项陕西省教委基金更多>>
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The Mechanism of Swainsonine Causing Early Pregnancy Abnormal Decidualization and Inducing Abortion by Changing Glycosylation Modification
《Advances in Reproductive Sciences》2018年第3期70-101,共32页Yi Wang Xin Gao Ming Peng Yanfei You Fangyun Shi Yazhou Guo Baoyu Zhao Chenchen Wu 
Locoweed is a poisonous plant that severely harms the development of grass-land and animal husbandry throughout the world. Oxytropis and Astragalus are the Latin names for the poisonous plants commonly known as locowe...
关键词:SWAINSONINE GLYCOSYLATION Modification ABORTION DECIDUA Hormone Cell Apoptosis Endoplasmic Reticulum Stress 
Advance of swainsonine biosynthesis被引量:5
《Chinese Chemical Letters》2018年第3期417-422,共6页Xiang-mei Tan Amanda Juan Chen Bin WU Gui-Shan Zhang Gang Ding 
financial support from the National Natural Science Foundation of China(No. 31570340, for G. Ding);The National Key Research and Development Program of China (No. 2017ZX09101003-006-006);the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Agricultural Sciences(No.502-17)
Swainsonine (1) belongs to the family of indolizine alkaloid with strong neurologically toxic effects on herbivorous livestock. Recently, a great amount of evidence confirmed that this alkaloid displayed a wide rang...
关键词:Swainsonine Indolizine Biosynthesis Isotope-labeled Gene Cluster 
Preparation of Polyclonal Antibody Against Swainsonine and Its Effects in Treatment of Oxytropis glabrapoisoned Rabbits
《Animal Husbandry and Feed Science》2014年第6期291-295,315,共6页Chen Genyuan Jia Qizhen Pan Yiwei Jia Shanling Wang Shuai 
Supported by Doctoral Fund of Xinjiang Production and Construction Corps(2008JC07);Open Fund of Key Laboratory of Tarim Animal Husbandry Science and Technology,Xin Jiang Production & Construction Corps(HS201207)
This study was conducted to optimize immunization program to gain the serum against swainsonine (SW) with high titer and to analyze the effects of polychinal antibody in treatment of loco disease of rabbits. Eightee...
关键词:Oxytropis glabra DC SWAINSONINE Polyclonal antibody TREATMENT RABBIT 
A concise formal stereoselective total synthesis of(-)-swainsonine被引量:1
《Chinese Chemical Letters》2014年第2期193-196,共4页Xiao-Gang Wang Ai-E Wang Pei-Qiang Huang 
financial support from the National Basic Research Program(973 Program)of China(No. 2010CB833200);the NSF of China(Nos.21332007,21072160);the Program for Changjiang Scholars and Innovative Research Team in University(PCSIRT)of Ministry of Education,China for financial support
A short formal stereoselective synthesis of (-)-swainsonine (1) is described. Our synthesis started with the versatile building block (R)-3-benzyloxyglutarimide 5. Through controlled regioselective reduction, Le...
关键词:lndolizidines ALKALOIDS α-Amidoalkylation Building blocks Stereoselective synthesis 
苦马豆素抗牛病毒性腹泻病毒的研究被引量:21
《中国农业科学》2014年第1期170-181,共12页郝宝成 武凡琳 邢小勇 项海涛 温峰琴 王学红 权晓弟 胡永浩 梁剑平 
国家高新技术研究发展计划("863"计划)(2011AA10A214);中央级公益性科研院所基本科研业务费专项资金(1610322012001);西藏农牧厅委托项目(2012-2014)
【目的】疯草是中国西部影响草地生态和畜牧业健康发展的毒草之一。主要有豆科棘豆属和黄芪属有毒植物等,在冬季牧草严重缺乏的时节,牛羊等牲畜被迫采食后可引起中毒和生产性能下降,甚至死亡,每年给我国草地生态和畜牧业造成的直接经济...
关键词:茎直黄芪 苦马豆素(SW) 牛病毒性腹泻病毒(BVDV) 抗病毒 SWAINSONINE (SW) bovine viral diarrhea virus (BVDV) 
Cellulase Extraction and Gas Chromatography Detection Technology of Swainsonine from Astragalus strictusin in Tibet
《Agricultural Science & Technology》2013年第8期1163-1166,共4页郝宝成 杨贤鹏 王学红 胡永浩 梁剑平 
中央级公益性科研院所基本科研业务费专项资金(1610322012001);国家高新技术研究发展计划(863计划)课题(2011AA10A214)~~
Locoweed is a poisonous plant wildly distributed in most areas of the world,which causes livestock poisoning or death with serious economic loss.The Astragalus strictus belongs to a species of Iocoweed.It is mainly di...
关键词:EXTRACTION Astragalus strictus SWAINSONINE CELLULASE GC 
苦马豆素人工抗原免疫小鼠的安全性试验
《湖北农业科学》2013年第14期3370-3372,3377,共4页陈根元 王帅 张玲 吴书奇 胡建军 马春晖 
国家自然科学基金项目(31160497);新疆生产建设兵团博士基金专项(2008JC07);新疆生产建设兵团塔里木畜牧科技重点实验室开放课题(HS201207)
通过分析苦马豆素(Swainsonine,SW)人工抗原SW-OVA对小鼠机体的影响,进行安全性评价。将36只昆明种小鼠随机分为对照组、试验Ⅰ组、试验Ⅱ组,每组12只。试验组依次进行首免和加强免疫,免疫前采血,分析血清生化指标谷草转氨酶(AST)、谷...
关键词:苦马豆素(Swainsonine SW) 人工抗原 免疫 小鼠 
Isolation and NMR Study on Swainsonine from Locoweed,Astragalus strictus被引量:8
《Agricultural Sciences in China》2009年第1期115-120,共6页ZHAO Bao-yu LIU Zhong-yan WANG Jian-jun SUN Li-sha WANG Zhan-xin WANG Yin-chao 
the National Natural Science Foundation of China (39770571)
Locoweed is a poisonous plant wildly distributed in most area of the world and can cause livestock poisoning or death with significant economic loss. The principal responsible for its toxicity is indolizidine alkaloid...
关键词:chemical shift assignment LOCOWEED NMR SWAINSONINE 
气相色谱-甲基化-α-D-甘露糖苷内标法测定变异黄芪中的苦马豆素被引量:14
《色谱》2007年第5期781-782,共2页赵兴华 崔忠华 耿果霞 王建华 张志敏 宋毓民 刘志滨 
国家自然科学基金资助项目(No30571315);博士点基金项目(No20030712017)
建立以甲基化-α-D-甘露糖苷为内标物,用气相色谱测定变异黄芪中苦马豆素的方法。植物样品经甲醇超声提取、氯仿去除杂质后,将碱性正丁醇萃取物用硅烷化试剂进行衍生化,通过AT.SE-54毛细管柱分离,氢火焰离子化检测器检测,测得变异黄芪...
关键词:气相色谱(GC) 疯草(locoweed) 苦马豆素(swainsonine) 衍生化(derivatization) 
离子抑制色谱法测定棘豆属植物提取物中的苦马豆素被引量:15
《色谱》2006年第6期656-656,共1页郭治安 张小辉 赵景婵 袁红安 梁小云 
陕西省教委基金资助项目(No.03JK075)
关键词:离子抑制色谱法(ion suppression chromatography) 苦马豆素(swainsonine) 植物提取物(plant extract) 棘豆属植物(Oxytropis) 
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