生长抑素类似物奥曲肽对胰腺癌细胞增殖的影响  

Effect of octreotide on cell proliferation in pancreatic adenocarcinoma

作　　者：全竹富[1] 何长生[1] 黄晓旭[1] 黎介寿[1] 

机构地区：[1]南京军区南京总医院解放军普通外科研究所,江苏南京210002

出　　处：《肠外与肠内营养》2009年第1期18-19,22,共3页Parenteral & Enteral Nutrition

基　　金：中华医学会外科学分会胰腺学组基金资助课题(2005-8)

摘　　要：目的:探讨生长抑素类似物奥曲肽对胰腺癌细胞增殖的影响。方法:对7例使用奥曲肽治疗(奥曲肽组)和9例未处理(对照组)的胰腺导管癌病人,用免疫组化法检测癌组织中Ki67表达。结果:奥曲肽组病人癌组织Ki67标记指数为(24.29±15.92)%;对照组为(34.1±15.36)%。奥曲肽组的Ki67标记指数显著低于对照组(P<0.05)。结论:生长抑素类似物奥曲肽有抑制胰腺癌病人癌细胞增殖的作用,可能在胰腺癌综合治疗中发挥作用。Objective ： The study was designed to investigate the effect of octreotide on the cell proliferation in pancreatic adenocarcinoma. Methods： The expressions of Ki67 in 7 cases of human pancreatic adenocarcinoma treated by octreotide and 9 cases untreated were detected by immunohistochemical EnVision technique. Results： The Ki67 expression was （24.29± 15.92）% in octreotide treated group and （34.1±15.36）% in untreated group. The Ki67 expression in the treated group was significantly lower than that in untreated group （P 〈 0.05 ）. Conclusion： The somatostatin analog （octreotide） may exert beneficial effects in the treatment of human pancreatic adenocarcinoma by inhibiting the cell proliferation.

关 键 词：奥曲肽 胰腺癌 细胞增殖 生长抑素类似物 

分 类 号：R735.9[医药卫生—肿瘤]