cyclin T1与β-catenin在肾透明细胞癌中的表达及意义  

Expression and roles of cyclin T1 and β-catenin in renal clear cell carcinoma

作　　者：陈弘[1] 林宗明[1] 许乐[1] 张建平[1] 王国民[1] 

机构地区：[1]复旦大学附属中山医院泌尿外科,上海200032

出　　处：《复旦学报（医学版）》2009年第1期37-40,共4页Fudan University Journal of Medical Sciences

基　　金：上海市科委自然科学基金项目(05ZR14029)

摘　　要：目的探讨cyclin T1与β-catenin在肾透明细胞癌中的表达及意义。方法采用免疫组化方法检测40例肾透明细胞癌和瘤旁正常组织中cyclin T1和β-catenin的表达。分别以χ2检验和非条件Logistic回归分析寻找与cyclin T1表达相关的因素。结果40例肾透明细胞癌中,37例(92.5%)cyclin T1表达阳性,其中14例(35%)为强阳性,肿瘤组织cyclin T1表达的阳性率显著高于正常肾组织(χ2=9.038,P=0.003);36例(90%)肿瘤胞质β-catenin呈阳性表达,其中18例(45%)呈强阳性表达。单因素χ2检验显示cyclin T1表达分别与肿瘤的分级、β-catenin的胞质表达相关(P分别为0.039、0.014),而与患者性别、年龄、肿瘤大小、TNM分期无关(P>0.05);Logistic多因素回归分析显示cyclin T1表达只与β-catenin的胞质表达有关(P=0.018)。结论肾透明细胞癌中cyclin T1表达增强,与肿瘤细胞的分化和β-catenin的胞质表达相关,可能是β-catenin下游目标基因产物之一。Objective To study cyclin T1 andβ-catenin＇s expression and their roles in renal clear cell carcinoma （RCCC）. Methods Cyclin T1 and β-catenin were investigated in 40 cases of RCCC and in the normal paratumor tissue by immumohistochemical staining. Non-condition Logistic analysis and Χ^2 test were used to search the correlating factors of cyclin T1 expression. Results In all the 40 cases of RCCC, 37 （92. 5%） showed positive cyelin T1 staining, among which 14 cases （35%） showed strong positive staining. The rate of positive expression of cyclin T1 staining in RCCC was significantly higher than that in normal kidney tissue （Χ^2 = 9. （138,P= 0. 003）. Thirty-six cases （90%） showed positive β-catenin expression in cytoplasm, among which 18 cases （45%） showed strong positive expression. Χ^2 test showed that cyclin T1 expression correlated with tumor grade or cytoplasmic β- catenin expression （P = 0. 039, 0. 014 respectively）, and had negative relations with gender, age, tumor size or tumor stage （P〉0.05）. Non-condition Logistic analysis showed that cyelin T1 only correlated with cytoplasmic β-catenin （P =0. 018）. Conclusions Cyctin T1, which is up-regulated in renal clear cell carnoma, correlates with the tumor differentiation and cytoplasmic β-catenin level, and can be one of the targets ofβ-catenin signal.

关 键 词：肾透明细胞癌 细胞周期蛋白T1 Β连环蛋白 Fuhrman分级 

分 类 号：R737.11[医药卫生—肿瘤]