P53和c-erbB-2基因在胃癌及其癌旁病变中的表达  

Expression of P53 and c-erbB-2 in castric cancer and it's pericancerous lesions

作　　者：吴先志 翟建英 张建中[1,2] 郑庆璇 郭风英[1,2] 张玉林 

机构地区：[1]宁夏石嘴山市第二医院病理科 [2]宁夏医学院病理学教研室

出　　处：《宁夏医学杂志》1998年第1期25-26,共2页Ningxia Medical Journal

基　　金：宁夏石嘴山市科委资助

摘　　要：目的为了研究胃癌发生发展的机理。方法采用免疫组化方法研究了８８例胃癌及其癌旁肠上皮化生、异型增生中Ｐ５３和ｃ－ｅｒｂＢ－２基因蛋白的表达。结果８８例胃癌中Ｐ５３和ｃ－ｅｒｂＢ－２蛋白阳性率分别为５２．３％和２０．５％；Ｐ５３在高分化腺癌和低分化腺癌的阳性率（分别为６１．８％和５７．９％），明显高于粘液癌（１８．８％，Ｐ＜０．０１）；癌旁肠上皮化生和异型增生中Ｐ５３全部为阴性；ｃ－ｅｒｂＢ－２在高分化腺癌和低分化腺癌中的阳性率有显著性差异（Ｐ＜０．０５）；癌旁肠上皮化生中ｃ－ｅｒｂＢ－２全部为阴性，中度以上不典型增生阳性率４．８％。结论Ｐ５３基因突变和ｃ－ｅｒｂＢ－２基因活化是胃粘膜上皮癌变的重要原因和标志。Objective in order to investigate the mechnism of gastric carcinogenesis and cancer develoepment.Methods The expression of P53 and c-erbB-2 genes in 88 cases of gastric carcinoma and its pericancerous intestinal metaplasia and dysplasia was studied by means of immunohistochemical technique. Results The results were showed that the positive expression of P53 and c-erbB-2 gene in 88 adenocarcinoma in stomach were 52.3% and 20. 5%, respectively. The positive expression of P53 in well-differentiated and lower-differentiated adenocarcinoma(61.8% and 57.9%,respectively)was significantly higher than that in mucous cancer(18.8%) ,P< 0. 01.Theintestinal metaplasia and dysplasia pericancerously was all negative staining of P53.The positive expression of c-erbB-2 in well-differentiated carcinoma was significantly higher than that in lower-differentiated one(P<0.05).The metaplasia was all negative. The dysplasia more than moderate grade was 4.8% positive expression.Conclusions it is suggested that the mutation of P53 and c-erbB-2 initiated be contributble to the carcinogenesis of gastric epithelium and be indicator of cancerous change

关 键 词：胃肿瘤 P53基因 癌旁病变 C-ERBB-2基因 

分 类 号：R735.202[医药卫生—肿瘤]