姜辣素在2种呕吐动物模型中止呕作用机制的探讨  

Mechanisms of antiemetic effect of gingerols in two vomiting animal models

作　　者：王耀霞[1] 杨志宏[1] 岳旺[1] 刘占涛[1] 韩庆方[1] 

机构地区：[1]青岛大学医学院,山东青岛266021

出　　处：《沈阳药科大学学报》2009年第2期134-137,164,共5页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(30873108);山东省自然科学基金资助项目(Y2007C097)

摘　　要：目的开发姜的止呕制剂,弥补临床上5-羟色胺Ⅲ亚型受体(5-hydroxytryptamine-3 receptor,5-HT3)及神经激肽Ⅰ亚型受体(neurokinin-1 receptor,NK1)拮抗剂靶点单一、价格昂贵、毒性及不良反应大等缺点。方法用特异性5-HT3受体激动剂1-phenylbiguanide hydrochloride(PBG)和多巴胺受体激动剂阿朴吗啡(apomorphine)建立新型水貂呕吐模型和经典大鼠异嗜模型,观察姜辣素对水貂呕吐行为和大鼠异嗜高岭土行为的抑制作用。结果姜辣素对水貂呕吐行为和大鼠异嗜高岭土行为均表现出显著的抑制作用(P<0.05),并呈现一定的量效关系。结论姜辣素有止呕作用,其止呕机制可能涉及到5-羟色胺和多巴胺受体系统;姜辣素在研究天然多靶点新型止呕药方面具有潜在的应用价值。Objective To explore an antiemetic drug of ginger in order to supplement the antagonists of 5-hydroxytryptamine-3 receptor（5-HT3 ） and neurokinin- 1 receptor （ NK1 ） in clinical, which are endowed with single target, high price and serious side-effect. Methods A new vomiting model of mink as well as classic pica model of rat was established with specific 5-HT3 receptor agonist 1-phenylbiguanide hydrochloride and dopamine receptor agonist apomorphine. The inhibitive effect of gingerols on vomiting behavior of minks and kaolin pica consumption of rats was observed. Results Gingerols displayed distinguished inhibitive effect on vomiting behavior of minks and kaolin consumption of rats in a dose-dependent manner （ P 〈 0.05 ）. Conclusions The study of gingerols in vomiting model of mink and pica model of rat suggests that gingerols exhibits antiemetic effect. The mechanisms may refer to the system of 5-hydroxytryptamine and dopamine receptors. The result indicates that gingerols is of latent applied value on the study of novel natural multitarget antiemetic drugs.

关 键 词：姜辣素 呕吐 水貂 5-羟色胺Ⅲ亚型受体激动剂 1-phenylbiguanide HYDROCHLORIDE 

分 类 号：R96[医药卫生—药理学]