前列腺组织中PTTG的表达及其意义  

Expression and its signification of PTTG in prostattic tissues

作　　者：曹希亮[1] 高江平[2] 于文朝 韩刚[2] 文载律[3] 洪宝发[2] 

机构地区：[1]解放军第97医院泌尿外科,江苏徐州221004 [2]解放军总医院泌尿外科 [3]解放军总医院病理科

出　　处：《临床泌尿外科杂志》2008年第12期922-924,930,共4页Journal of Clinical Urology

摘　　要：目的:研究垂体肿瘤转化基因(PTTG)在前列腺组织,尤其是前列腺癌组织中的表达及临床意义。方法:采用免疫组织化学二步法检测正常前列腺(8例)、BPH(16例)、无远处转移的前列腺癌(47例)以及有远处转移的前列腺癌(19例)组织中PTTG的表达情况。用Stata统计软件分别对BPH和前列腺癌组织中PTTG的表达情况与PSA和Gleason分级间的关系进行分析。结果:PTTG在正常前列腺和BPH组织中无表达或弱表达,而63.7%(42/66)的前列腺癌中有阳性或强阳性表达,在良恶性前列腺组织之间的表达差异有统计学意义(x^2= 25.2487,P=0.000),无远处转移的前列腺癌和有远处转移的前列腺癌之间的表达差异无统计学意义(x^2=0.3568, P=0.837)。PTTG在前列腺癌中的表达与PSA和Gleason分级之间无相关性。结论:PTTG在前列腺癌组织中高表达,可能在前列腺癌的发生发展过程中起重要作用。Objective：To investigate expression of PTTG and its signification in prostatic tissues, especially in prostate cancer. Methods：The expression of PTTG was detected with two-step immunohistochemical staining technique in 8 cases of normal prostatic tissues, 16 cases of BPH, 47 cases of non-metastasis prostate cancer and 19 cases of metastasis pros- tate cancer. The PTTG expression situation of normal prostatic tissue, BPH and prostate cancer was analysed by Stata as well as the relationship between the PTTG expression in prostate cancer and PSA and Gleason grade. Results：PTTG ex- pression was found in 42 of 66 （63.70%） of prostate cancer tissues, no marked expression was found in normal and BPH tissues. There was significantly different expression between Benign and malignant prostate tissue（x2= 25. 2487, P= 0. 000）. No significantly different expression between non metastasis prostate cancer and metastasis prostate cancer. No association was found between PTTG expression and Gleason score or pretreatment PSA. Conclusions： These data sugges- ted that there is significant PTTG overexpression in prostate cancer tissues, which may indicate PTTG playing a important role in the development of prostate cancer.

关 键 词：前列腺腺癌 良性前列腺增生 垂体肿瘤转化基因 免疫组织化学法 

分 类 号：R737.25[医药卫生—肿瘤]