^(31)P磁共振波谱物质检测准确性的验证研究  

Verification Study on the Accuracy of Substance Detection with 31P MRS

作　　者：杜飞舟[1] 丁仕义[2] 顾明[1] 何次[1] 

机构地区：[1]成都军区总医院放射科,四川成都610083 [2]重庆西南医院放射科,重庆400038

出　　处：《现代生物医学进展》2009年第2期263-264,262,共3页Progress in Modern Biomedicine

摘　　要：目的:评价1.5T磁场下31PMRS磷化合物检测的准确性。方法:以卵磷脂为参照标准品,对照研究对同一位正常志愿者骨骼肌肉磷谱代谢特征,对其股骨下端先后行两次相同参数、相同条件状态下的31P波谱检测,第二次检测时在感兴趣区内体外加入卵磷脂标准品,对比两次检测的结果变化。结果:对同一位正常志愿者先后两次进行波谱检测,加入卵磷脂后各代谢物波谱变化为β-ATP:-24.46,α-ATP:+82.61,γ-ATP:-32.89,PCr:+64.32,Pi:+110.5,PDE:+462.57,PME:+15.71。加入卵磷脂后,PDE峰改变最明显。结论:1.5T磁场下31PMRS能准确检测体内化合物的存在及其定量分析,研究结果可信。Objective： To evaluate the accuracy and the feasibility of the ^31p MRS detection by adding the lecithin into the volume of interest （VOI）. Methods： The detection with ^31p MRS was performed twice on the same volunteer. By adding the lecithin into the VOI, we checked up the accuracy and the feasibility of the MRS examination by studying the changes between the two detections. Resuits： Different results were obtained from the two detections of ^31p MRS on the same volunteer. After adding the lecithin in to the VOI, the changes of the spectra were as follow： β-ATP：-24.46, α-ATP： ＋82.61, γ-ATP：-32.89, PCr：＋64.32, Pi：＋110.5, PDE：＋462.57, PME： ＋ 15.71. The PDE peak changed most significantly. Conclusion： The research of the chemical shift of lecithin indicates that 31P MRS is an accurate method of compounds detection and quantitative analysis.

关 键 词：^31P 磁共振波谱学 卵磷脂 

分 类 号：R445.2[医药卫生—影像医学与核医学]