COX-2介导的TH2类细胞因子与重症肝炎的关系研究  

The TH2 Subgroup Cytokines Mediated Downstream Effector COX-2'S Function in the Progression of Serious Hepatitis

作　　者：李斌[1] 潘粉丽[2] 常崇旺[3] 

机构地区：[1]第四军医大学唐都医院信息科,陕西西安710038 [2]第四军医大学唐都医院设备科,陕西西安710038 [3]第四军医大学唐都医院神经外科,陕西西安710038

出　　处：《现代生物医学进展》2009年第2期268-270,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(NO.30701005)

摘　　要：目的:探讨重症肝炎与COX-2的关系,为临床防治重症肝炎提供新的治疗理论和方法。方法:用FH643A-γ测量仪检测50例肝病患者和25例正常对照血清中PGs代谢产物TXB2、6-keto-PGF1α的水平。结果:各组肝病患者血清中TXB2和6-keto-PGF1α的表达水平均明显高于正常人(P<0.001),并且随着病情的好转,T/6-K比值明显下降,但肝病患者各组间细胞因子水平无显著性差异(p>0.05)。结论:检测重症肝炎患者血清TXB2、6-keto-PGF1α的水平和T/6-K比值不仅对揭示肝病发生发展过程有一定的实用价值,而且对监测病情转归和预后有重要临床意义。Objective： To study the TH2 subgroup cytokines mediated downstream effector COX-2＇s function in the progression of serious hepatitis; Methods： Samples from a total of 50 serious hepatitis patients with well-characterised clinical profiles and 25 healthy controls were assessed by ELISA. Results： Compared with the healthy control group, serum TXB2 and 6-keto-PGFlodevel were uniformly elevated in all serious hepatitis patients （P〈0.01）. But there was no significant difference of these eytokines levels among the different types of serious hepatitis patients （p〉0.05）. Conclusions： Product of COX-2 metabolism TXB2 and 6ketoPGF 16-keto-PGFlctwere associated with the clinical progression of serious hepatitis, especially T/6-K ratio was an effective biological marker for prognosis and diagnosis for serious hepatitis.

关 键 词：重症肝炎 COX-2 细胞因子 

分 类 号：R575.1[医药卫生—消化系统]